Cardiac Nuclear High-Mobility Group Box 1 Ameliorates Pathological Cardiac Hypertrophy by Inhibiting DNA Damage Response

High-mobility group box 1 (HMGB1) is a deoxyribonucleic acid (DNA)–binding protein associated with DNA repair. Decreased nuclear HMGB1 expression and increased DNA damage response (DDR) were observed in human failing hearts. DNA damage and DDR as well as cardiac remodeling were suppressed in cardiac...

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Detalles Bibliográficos
Autores principales: Takahashi, Tetsuya, Shishido, Tetsuro, Kinoshita, Daisuke, Watanabe, Ken, Toshima, Taku, Sugai, Takayuki, Narumi, Taro, Otaki, Yoichiro, Tamura, Harutoshi, Nishiyama, Satoshi, Arimoto, Takanori, Takahashi, Hiroki, Miyamoto, Takuya, Watanabe, Tetsu, Woo, Chang-Hoon, Abe, Jun-ichi, Takeishi, Yasuchika, Kubota, Isao, Watanabe, Masafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488753/
https://www.ncbi.nlm.nih.gov/pubmed/31061925
http://dx.doi.org/10.1016/j.jacbts.2018.11.011

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