Elamipretide Improves Mitochondrial Function in the Failing Human Heart

Negative alterations of mitochondria are known to occur in heart failure (HF). This study investigated the novel mitochondrial-targeted therapeutic agent elamipretide on mitochondrial and supercomplex function in failing human hearts ex vivo. Freshly explanted failing and nonfailing ventricular tiss...

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Autores principales: Chatfield, Kathryn C., Sparagna, Genevieve C., Chau, Sarah, Phillips, Elisabeth K., Ambardekar, Amrut V., Aftab, Muhammad, Mitchell, Max B., Sucharov, Carmen C., Miyamoto, Shelley D., Stauffer, Brian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
CLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488757/
https://www.ncbi.nlm.nih.gov/pubmed/31061916
http://dx.doi.org/10.1016/j.jacbts.2018.12.005
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author Chatfield, Kathryn C.
Sparagna, Genevieve C.
Chau, Sarah
Phillips, Elisabeth K.
Ambardekar, Amrut V.
Aftab, Muhammad
Mitchell, Max B.
Sucharov, Carmen C.
Miyamoto, Shelley D.
Stauffer, Brian L.
author_facet Chatfield, Kathryn C.
Sparagna, Genevieve C.
Chau, Sarah
Phillips, Elisabeth K.
Ambardekar, Amrut V.
Aftab, Muhammad
Mitchell, Max B.
Sucharov, Carmen C.
Miyamoto, Shelley D.
Stauffer, Brian L.
author_sort Chatfield, Kathryn C.
collection PubMed
description Negative alterations of mitochondria are known to occur in heart failure (HF). This study investigated the novel mitochondrial-targeted therapeutic agent elamipretide on mitochondrial and supercomplex function in failing human hearts ex vivo. Freshly explanted failing and nonfailing ventricular tissue from children and adults was treated with elamipretide. Mitochondrial oxygen flux, complex (C) I and CIV activities, and in-gel activity of supercomplex assembly were measured. Mitochondrial function was impaired in the failing human heart, and mitochondrial oxygen flux, CI and CIV activities, and supercomplex-associated CIV activity significantly improved in response to elamipretide treatment. Elamipretide significantly improved failing human mitochondrial function.
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spelling pubmed-64887572019-05-06 Elamipretide Improves Mitochondrial Function in the Failing Human Heart Chatfield, Kathryn C. Sparagna, Genevieve C. Chau, Sarah Phillips, Elisabeth K. Ambardekar, Amrut V. Aftab, Muhammad Mitchell, Max B. Sucharov, Carmen C. Miyamoto, Shelley D. Stauffer, Brian L. JACC Basic Transl Sci CLINICAL RESEARCH Negative alterations of mitochondria are known to occur in heart failure (HF). This study investigated the novel mitochondrial-targeted therapeutic agent elamipretide on mitochondrial and supercomplex function in failing human hearts ex vivo. Freshly explanted failing and nonfailing ventricular tissue from children and adults was treated with elamipretide. Mitochondrial oxygen flux, complex (C) I and CIV activities, and in-gel activity of supercomplex assembly were measured. Mitochondrial function was impaired in the failing human heart, and mitochondrial oxygen flux, CI and CIV activities, and supercomplex-associated CIV activity significantly improved in response to elamipretide treatment. Elamipretide significantly improved failing human mitochondrial function. Elsevier 2019-04-29 /pmc/articles/PMC6488757/ /pubmed/31061916 http://dx.doi.org/10.1016/j.jacbts.2018.12.005 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle CLINICAL RESEARCH
Chatfield, Kathryn C.
Sparagna, Genevieve C.
Chau, Sarah
Phillips, Elisabeth K.
Ambardekar, Amrut V.
Aftab, Muhammad
Mitchell, Max B.
Sucharov, Carmen C.
Miyamoto, Shelley D.
Stauffer, Brian L.
Elamipretide Improves Mitochondrial Function in the Failing Human Heart
title Elamipretide Improves Mitochondrial Function in the Failing Human Heart
title_full Elamipretide Improves Mitochondrial Function in the Failing Human Heart
title_fullStr Elamipretide Improves Mitochondrial Function in the Failing Human Heart
title_full_unstemmed Elamipretide Improves Mitochondrial Function in the Failing Human Heart
title_short Elamipretide Improves Mitochondrial Function in the Failing Human Heart
title_sort elamipretide improves mitochondrial function in the failing human heart
topic CLINICAL RESEARCH
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488757/
https://www.ncbi.nlm.nih.gov/pubmed/31061916
http://dx.doi.org/10.1016/j.jacbts.2018.12.005
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