Glucagon-Like Peptide-1–Mediated Cardioprotection Does Not Reduce Right Ventricular Stunning and Cumulative Ischemic Dysfunction After Coronary Balloon Occlusion

Stunning and cumulative ischemic dysfunction occur in the left ventricle with coronary balloon occlusion. Glucagon-like peptide (GLP)-1 protects the left ventricle against this dysfunction. This study used a conductance catheter method to evaluate whether the right ventricle (RV) developed similar d...

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Autores principales: Giblett, Joel P., Axell, Richard G., White, Paul A., Aetesam-Ur-Rahman, Muhammad, Clarke, Sophie J., Figg, Nicola, Bennett, Martin R., West, Nick E.J., Hoole, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488814/
https://www.ncbi.nlm.nih.gov/pubmed/31061924
http://dx.doi.org/10.1016/j.jacbts.2018.12.002
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author Giblett, Joel P.
Axell, Richard G.
White, Paul A.
Aetesam-Ur-Rahman, Muhammad
Clarke, Sophie J.
Figg, Nicola
Bennett, Martin R.
West, Nick E.J.
Hoole, Stephen P.
author_facet Giblett, Joel P.
Axell, Richard G.
White, Paul A.
Aetesam-Ur-Rahman, Muhammad
Clarke, Sophie J.
Figg, Nicola
Bennett, Martin R.
West, Nick E.J.
Hoole, Stephen P.
author_sort Giblett, Joel P.
collection PubMed
description Stunning and cumulative ischemic dysfunction occur in the left ventricle with coronary balloon occlusion. Glucagon-like peptide (GLP)-1 protects the left ventricle against this dysfunction. This study used a conductance catheter method to evaluate whether the right ventricle (RV) developed similar dysfunction during right coronary artery balloon occlusion and whether GLP-1 was protective. In this study, the RV underwent significant stunning and cumulative ischemic dysfunction with right coronary artery balloon occlusion. However, GLP-1 did not protect the RV against this dysfunction when infused after balloon occlusion.
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spelling pubmed-64888142019-05-06 Glucagon-Like Peptide-1–Mediated Cardioprotection Does Not Reduce Right Ventricular Stunning and Cumulative Ischemic Dysfunction After Coronary Balloon Occlusion Giblett, Joel P. Axell, Richard G. White, Paul A. Aetesam-Ur-Rahman, Muhammad Clarke, Sophie J. Figg, Nicola Bennett, Martin R. West, Nick E.J. Hoole, Stephen P. JACC Basic Transl Sci PRECLINICAL RESEARCH Stunning and cumulative ischemic dysfunction occur in the left ventricle with coronary balloon occlusion. Glucagon-like peptide (GLP)-1 protects the left ventricle against this dysfunction. This study used a conductance catheter method to evaluate whether the right ventricle (RV) developed similar dysfunction during right coronary artery balloon occlusion and whether GLP-1 was protective. In this study, the RV underwent significant stunning and cumulative ischemic dysfunction with right coronary artery balloon occlusion. However, GLP-1 did not protect the RV against this dysfunction when infused after balloon occlusion. Elsevier 2019-04-29 /pmc/articles/PMC6488814/ /pubmed/31061924 http://dx.doi.org/10.1016/j.jacbts.2018.12.002 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle PRECLINICAL RESEARCH
Giblett, Joel P.
Axell, Richard G.
White, Paul A.
Aetesam-Ur-Rahman, Muhammad
Clarke, Sophie J.
Figg, Nicola
Bennett, Martin R.
West, Nick E.J.
Hoole, Stephen P.
Glucagon-Like Peptide-1–Mediated Cardioprotection Does Not Reduce Right Ventricular Stunning and Cumulative Ischemic Dysfunction After Coronary Balloon Occlusion
title Glucagon-Like Peptide-1–Mediated Cardioprotection Does Not Reduce Right Ventricular Stunning and Cumulative Ischemic Dysfunction After Coronary Balloon Occlusion
title_full Glucagon-Like Peptide-1–Mediated Cardioprotection Does Not Reduce Right Ventricular Stunning and Cumulative Ischemic Dysfunction After Coronary Balloon Occlusion
title_fullStr Glucagon-Like Peptide-1–Mediated Cardioprotection Does Not Reduce Right Ventricular Stunning and Cumulative Ischemic Dysfunction After Coronary Balloon Occlusion
title_full_unstemmed Glucagon-Like Peptide-1–Mediated Cardioprotection Does Not Reduce Right Ventricular Stunning and Cumulative Ischemic Dysfunction After Coronary Balloon Occlusion
title_short Glucagon-Like Peptide-1–Mediated Cardioprotection Does Not Reduce Right Ventricular Stunning and Cumulative Ischemic Dysfunction After Coronary Balloon Occlusion
title_sort glucagon-like peptide-1–mediated cardioprotection does not reduce right ventricular stunning and cumulative ischemic dysfunction after coronary balloon occlusion
topic PRECLINICAL RESEARCH
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488814/
https://www.ncbi.nlm.nih.gov/pubmed/31061924
http://dx.doi.org/10.1016/j.jacbts.2018.12.002
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