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Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: Expert consensus on the use of Ginkgo biloba extract, EGb 761(®)

BACKGROUND: The Ginkgo biloba special extract, EGb 761(®) has been widely used in the treatment of neuropsychiatric disorders, including Alzheimer’s disease (AD). METHODS: To guide clinical practice in the Asian region, the Asian Clinical Expert Group on Neurocognitive Disorders compiled evidence‐ba...

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Autores principales: Kandiah, Nagaendran, Ong, Paulus Anam, Yuda, Turana, Ng, Li‐Ling, Mamun, Kaysar, Merchant, Reshma Aziz, Chen, Christopher, Dominguez, Jacqueline, Marasigan, Simeon, Ampil, Encarnita, Nguyen, Van Thong, Yusoff, Suraya, Chan, Yee Fai, Yong, Fee Mann, Krairit, Orapitchaya, Suthisisang, Chuthamanee, Senanarong, Vorapun, Ji, Yong, Thukral, Ramesh, Ihl, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488894/
https://www.ncbi.nlm.nih.gov/pubmed/30648358
http://dx.doi.org/10.1111/cns.13095
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author Kandiah, Nagaendran
Ong, Paulus Anam
Yuda, Turana
Ng, Li‐Ling
Mamun, Kaysar
Merchant, Reshma Aziz
Chen, Christopher
Dominguez, Jacqueline
Marasigan, Simeon
Ampil, Encarnita
Nguyen, Van Thong
Yusoff, Suraya
Chan, Yee Fai
Yong, Fee Mann
Krairit, Orapitchaya
Suthisisang, Chuthamanee
Senanarong, Vorapun
Ji, Yong
Thukral, Ramesh
Ihl, Ralf
author_facet Kandiah, Nagaendran
Ong, Paulus Anam
Yuda, Turana
Ng, Li‐Ling
Mamun, Kaysar
Merchant, Reshma Aziz
Chen, Christopher
Dominguez, Jacqueline
Marasigan, Simeon
Ampil, Encarnita
Nguyen, Van Thong
Yusoff, Suraya
Chan, Yee Fai
Yong, Fee Mann
Krairit, Orapitchaya
Suthisisang, Chuthamanee
Senanarong, Vorapun
Ji, Yong
Thukral, Ramesh
Ihl, Ralf
author_sort Kandiah, Nagaendran
collection PubMed
description BACKGROUND: The Ginkgo biloba special extract, EGb 761(®) has been widely used in the treatment of neuropsychiatric disorders, including Alzheimer’s disease (AD). METHODS: To guide clinical practice in the Asian region, the Asian Clinical Expert Group on Neurocognitive Disorders compiled evidence‐based consensus recommendations regarding the use of EGb 761(®) in neurocognitive disorders with/without cerebrovascular disease. RESULTS: Key randomized trials and robust meta‐analyses have demonstrated significant improvement in cognitive function, neuropsychiatric symptoms, activities of daily living (ADL) and quality of life with EGb 761(®)versus placebo in patients with mild‐to‐moderate dementia. In those with mild cognitive impairment (MCI), EGb 761(®) has also demonstrated significant symptomatic improvement versus placebo. World Federation of Societies of Biological Psychiatry guidelines list EGb 761(®) with the same strength of evidence as acetylcholinesterase inhibitors and N‐methyl‐D‐aspartate (NMDA) antagonists e.g. memantine (Grade 3 recommendation; Level B evidence). Only EGb 761(®) had Level B evidence in improving cognition, behaviour, and ADL in both AD and vascular dementia patients. Safety analyses show EGb 761(®) to have a positive risk‐benefit profile. While concerns have been raised regarding a possible increased bleeding risk, several randomized trials and two meta‐analyses have not supported this association. CONCLUSIONS: The Expert Group foresee an important role for EGb 761(®), used alone or as an add‐on therapy, in the treatment of MCI and dementias, particularly when patients do not derive benefit from acetylcholinesterase inhibitors or NMDA antagonists. EGb 761(®) should be used in alignment with local clinical practice guidelines.
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spelling pubmed-64888942019-06-26 Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: Expert consensus on the use of Ginkgo biloba extract, EGb 761(®) Kandiah, Nagaendran Ong, Paulus Anam Yuda, Turana Ng, Li‐Ling Mamun, Kaysar Merchant, Reshma Aziz Chen, Christopher Dominguez, Jacqueline Marasigan, Simeon Ampil, Encarnita Nguyen, Van Thong Yusoff, Suraya Chan, Yee Fai Yong, Fee Mann Krairit, Orapitchaya Suthisisang, Chuthamanee Senanarong, Vorapun Ji, Yong Thukral, Ramesh Ihl, Ralf CNS Neurosci Ther Clinical Guidelines BACKGROUND: The Ginkgo biloba special extract, EGb 761(®) has been widely used in the treatment of neuropsychiatric disorders, including Alzheimer’s disease (AD). METHODS: To guide clinical practice in the Asian region, the Asian Clinical Expert Group on Neurocognitive Disorders compiled evidence‐based consensus recommendations regarding the use of EGb 761(®) in neurocognitive disorders with/without cerebrovascular disease. RESULTS: Key randomized trials and robust meta‐analyses have demonstrated significant improvement in cognitive function, neuropsychiatric symptoms, activities of daily living (ADL) and quality of life with EGb 761(®)versus placebo in patients with mild‐to‐moderate dementia. In those with mild cognitive impairment (MCI), EGb 761(®) has also demonstrated significant symptomatic improvement versus placebo. World Federation of Societies of Biological Psychiatry guidelines list EGb 761(®) with the same strength of evidence as acetylcholinesterase inhibitors and N‐methyl‐D‐aspartate (NMDA) antagonists e.g. memantine (Grade 3 recommendation; Level B evidence). Only EGb 761(®) had Level B evidence in improving cognition, behaviour, and ADL in both AD and vascular dementia patients. Safety analyses show EGb 761(®) to have a positive risk‐benefit profile. While concerns have been raised regarding a possible increased bleeding risk, several randomized trials and two meta‐analyses have not supported this association. CONCLUSIONS: The Expert Group foresee an important role for EGb 761(®), used alone or as an add‐on therapy, in the treatment of MCI and dementias, particularly when patients do not derive benefit from acetylcholinesterase inhibitors or NMDA antagonists. EGb 761(®) should be used in alignment with local clinical practice guidelines. John Wiley and Sons Inc. 2019-01-15 /pmc/articles/PMC6488894/ /pubmed/30648358 http://dx.doi.org/10.1111/cns.13095 Text en © 2018 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Guidelines
Kandiah, Nagaendran
Ong, Paulus Anam
Yuda, Turana
Ng, Li‐Ling
Mamun, Kaysar
Merchant, Reshma Aziz
Chen, Christopher
Dominguez, Jacqueline
Marasigan, Simeon
Ampil, Encarnita
Nguyen, Van Thong
Yusoff, Suraya
Chan, Yee Fai
Yong, Fee Mann
Krairit, Orapitchaya
Suthisisang, Chuthamanee
Senanarong, Vorapun
Ji, Yong
Thukral, Ramesh
Ihl, Ralf
Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: Expert consensus on the use of Ginkgo biloba extract, EGb 761(®)
title Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: Expert consensus on the use of Ginkgo biloba extract, EGb 761(®)
title_full Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: Expert consensus on the use of Ginkgo biloba extract, EGb 761(®)
title_fullStr Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: Expert consensus on the use of Ginkgo biloba extract, EGb 761(®)
title_full_unstemmed Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: Expert consensus on the use of Ginkgo biloba extract, EGb 761(®)
title_short Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: Expert consensus on the use of Ginkgo biloba extract, EGb 761(®)
title_sort treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: expert consensus on the use of ginkgo biloba extract, egb 761(®)
topic Clinical Guidelines
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488894/
https://www.ncbi.nlm.nih.gov/pubmed/30648358
http://dx.doi.org/10.1111/cns.13095
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