Cargando…

PM2.5 induces cell cycle arrest through regulating mTOR/P70S6K1 signaling pathway

Fine particulate matter (PM2.5) pollution has become a serious problem in China. This study aims to elucidate the toxicity mechanism of PM2.5. Protein levels were detected by western blotting and RT-qPCR, and cell cycle was detected by flow cytometry. The results showed that exposure to PM2.5 induce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yu, Yang, Dan, Yang, Biao, Li, Bingyu, Guo, Jie, Xiao, Chunling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489014/ https://www.ncbi.nlm.nih.gov/pubmed/31086573 http://dx.doi.org/10.3892/etm.2019.7466

Ejemplares similares

Benzoxazole Derivative K313 Induces Cell Cycle Arrest, Apoptosis and Autophagy Blockage and Suppresses mTOR/p70S6K Pathway in Nalm-6 and Daudi Cells
por: Zhong, Wenying, et al.
Publicado: (2020)

PI3K/AKT/mTOR/p70S6K Pathway Is Involved in Aβ25-35-Induced Autophagy
por: Fan, Shengnuo, et al.
Publicado: (2015)

The mTOR/p70S6K1 signaling pathway in renal fibrosis of children with immunoglobulin A nephropathy
por: Xu, Yuanyuan, et al.
Publicado: (2017)

Ma xing shi gan decoction eliminates PM2.5-induced lung injury by reducing pulmonary cell apoptosis through Akt/mTOR/p70S6K pathway in rats
por: Wang, Yefang, et al.
Publicado: (2020)

Polydatin regulates proliferation, apoptosis and autophagy in multiple myeloma cells through mTOR/p70s6k pathway
por: Yang, Baojun, et al.
Publicado: (2017)

Expression of mTOR/70S6K signaling pathway in pathological scar fibroblasts and the effects of resveratrol intervention
por: Tang, Zhi-Ming, et al.
Publicado: (2017)

Aberrant overexpression of ADAR1 promotes gastric cancer progression by activating mTOR/p70S6K signaling
por: Dou, Ning, et al.
Publicado: (2016)

Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer
por: Heinonen, Henna, et al.
Publicado: (2008)

PSMD7 downregulation induces apoptosis and suppresses tumorigenesis of esophageal squamous cell carcinoma via the mTOR/p70S6K pathway
por: Shi, Ke, et al.
Publicado: (2018)

Heparin-Binding EGF-Like Growth Factor Induces Heart Interstitial Fibrosis via an Akt/mTor/p70s6k Pathway
por: Lian, Hong, et al.
Publicado: (2012)

AKT/mTOR substrate P70S6K is frequently phosphorylated in gallbladder cancer tissue and cell lines
por: Leal, Pamela, et al.
Publicado: (2013)

Puerarin inhibits bladder cancer cell proliferation through the mTOR/p70S6K signaling pathway
por: Jiang, Kehua, et al.
Publicado: (2018)

MECP2 Mutation Interrupts Nucleolin–mTOR–P70S6K Signaling in Rett Syndrome Patients
por: Olson, Carl O., et al.
Publicado: (2018)

MiR-497 decreases cisplatin resistance in ovarian cancer cells by targeting mTOR/P70S6K1
por: Xu, Shaohua, et al.
Publicado: (2015)

TOFA induces cell cycle arrest and apoptosis in ACHN and 786-O cells through inhibiting PI3K/Akt/mTOR pathway
por: He, Dejiao, et al.
Publicado: (2018)

The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer
por: Trinh, X B, et al.
Publicado: (2009)

The role of mTOR and phospho-p70S6K in pathogenesis and progression of gastric carcinomas: an immunohistochemical study on tissue microarray
por: Xiao, Li, et al.
Publicado: (2009)

Carnosine Inhibits the Proliferation of Human Gastric Carcinoma Cells by Retarding Akt/mTOR/p70S6K Signaling
por: Zhang, Zhenwei, et al.
Publicado: (2014)

Effects of bufalin on the mTOR/p70S6K pathway and apoptosis in esophageal squamous cell carcinoma in nude mice
por: Liu, Yao, et al.
Publicado: (2017)

Effects of Akt/mTOR/p70S6K Signaling Pathway Regulation on Neuron Remodeling Caused by Translocation Repair
por: Yuan, Yusong, et al.
Publicado: (2020)

Upregulation of CENPM facilitates tumor metastasis via the mTOR/p70S6K signaling pathway in pancreatic cancer
por: Zheng, Chenlei, et al.
Publicado: (2020)

Rapamycin enhanced the antitumor effects of doxorubicin in myelogenous leukemia K562 cells by downregulating the mTOR/p70S6K pathway
por: Li, Jie, et al.
Publicado: (2019)

mTOR-S6K1 pathway mediates cytoophidium assembly
por: Sun, Zhe, et al.
Publicado: (2019)

PM2.5 Synergizes With Pseudomonas aeruginosa to Suppress Alveolar Macrophage Function in Mice Through the mTOR Pathway
por: Zhang, Jianlong, et al.
Publicado: (2022)

Fingolimod suppresses neuronal autophagy through the mTOR/p70S6K pathway and alleviates ischemic brain damage in mice
por: Li, Xiao, et al.
Publicado: (2017)

Autophagy activated by tuberin/mTOR/p70S6K suppression is a protective mechanism against local anaesthetics neurotoxicity
por: Xiong, Jingwei, et al.
Publicado: (2016)

Eugenol Attenuates Cerebral Ischemia-Reperfusion Injury by Enhancing Autophagy via AMPK-mTOR-P70S6K Pathway
por: Sun, Xiaowei, et al.
Publicado: (2020)

Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway
por: Shui, Liyan, et al.
Publicado: (2020)

Human milk extracellular vesicles enhance muscle growth and physical performance of immature mice associating with Akt/mTOR/p70s6k signaling pathway
por: Meng, Zitong, et al.
Publicado: (2023)

Suppression of PI3K/Akt/mTOR/c-Myc/mtp53 Positive Feedback Loop Induces Cell Cycle Arrest by Dual PI3K/mTOR Inhibitor PQR309 in Endometrial Cancer Cell Lines
por: Hsin, I-Lun, et al.
Publicado: (2021)

4-Hydroxyderricin Promotes Apoptosis and Cell Cycle Arrest through Regulating PI3K/AKT/mTOR Pathway in Hepatocellular Cells
por: Gao, Xiang, et al.
Publicado: (2021)

Human Positive Coactivator 4 Affects the Progression and Prognosis of Pancreatic Ductal Adenocarcinoma via the mTOR/P70s6k Signaling Pathway
por: Su, Xingxing, et al.
Publicado: (2020)

Inhibition of TRIM32 by ibr‐7 treatment sensitizes pancreatic cancer cells to gemcitabine via mTOR/p70S6K pathway
por: Zhang, Bo, et al.
Publicado: (2021)

Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer
por: Sridharan, Savitha, et al.
Publicado: (2020)

Irisin Ameliorates PM2.5-Induced Acute Lung Injury by Regulation of Autophagy Through AMPK/mTOR Pathway
por: Ma, Jiao, et al.
Publicado: (2023)

Inhibition of Akt/mTOR/p70S6K Signaling Activity With Huangkui Capsule Alleviates the Early Glomerular Pathological Changes in Diabetic Nephropathy
por: Wu, Wei, et al.
Publicado: (2018)

Aqueous Extract and Polysaccharide of Aconiti Lateralis Radix Induce Apoptosis and G0/G1 Phase Cell Cycle Arrest by PI3K/AKT/mTOR Signaling Pathway in Mesangial Cells
por: Li, Xingyao, et al.
Publicado: (2022)

Phenformin Induces Cell Cycle Change, Apoptosis, and Mesenchymal-Epithelial Transition and Regulates the AMPK/mTOR/p70s6k and MAPK/ERK Pathways in Breast Cancer Cells
por: Liu, Zhao, et al.
Publicado: (2015)

Botanical Drug Puerarin Ameliorates Liposaccharide-Induced Depressive Behaviors in Mice via Inhibiting RagA/mTOR/p70S6K Pathways
por: Zhao, Jia, et al.
Publicado: (2021)

The Inhibition of Insulin-stimulated Proliferation of Vascular Smooth Muscle Cells by Rosiglitazone Is Mediated by the Akt-mTOR-P70S6K Pathway
por: Park, Sungha, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_ppig9u9qr6pk0jtpe2b4oldh5c