Clinically Relevant Response to Cisplatin-5-Fluorouracyl in Intestinal-Type Sinonasal Adenocarcinoma with Loss of Vision: A Case Report

A 68-year-old man presented with rapid progressive visual loss caused by a progressive local invasive sinonasal intestinal-type adenocarcinoma (ITAC) with intracranial invasion. The local relapse of ITAC in the ethmoid sinus was previously treated with palliative radiotherapy and carboplatin-paclita...

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Autores principales: Claus, Jonas, Jorissen, Mark, Vander Poorten, Vincent, Nuyts, Sandra, Hermans, Robert, Casteels, Ingele, Clement, Paul M.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489020/
https://www.ncbi.nlm.nih.gov/pubmed/31097936
http://dx.doi.org/10.1159/000499602
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author Claus, Jonas
Jorissen, Mark
Vander Poorten, Vincent
Nuyts, Sandra
Hermans, Robert
Casteels, Ingele
Clement, Paul M.J.
author_facet Claus, Jonas
Jorissen, Mark
Vander Poorten, Vincent
Nuyts, Sandra
Hermans, Robert
Casteels, Ingele
Clement, Paul M.J.
author_sort Claus, Jonas
collection PubMed
description A 68-year-old man presented with rapid progressive visual loss caused by a progressive local invasive sinonasal intestinal-type adenocarcinoma (ITAC) with intracranial invasion. The local relapse of ITAC in the ethmoid sinus was previously treated with palliative radiotherapy and carboplatin-paclitaxel, without response, hence disease progression was seen. Ophthalmological examination revealed irreversible blindness of the left eye and a dramatic progressive visual loss of the right eye. Due to important visual loss caused by optic nerve invasion, a palliative treatment with cisplatin-5-fluorouracyl was started. This therapy resulted in a good clinical response with a regression of the local mass and a partial recovery of the vision.
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spelling pubmed-64890202019-05-16 Clinically Relevant Response to Cisplatin-5-Fluorouracyl in Intestinal-Type Sinonasal Adenocarcinoma with Loss of Vision: A Case Report Claus, Jonas Jorissen, Mark Vander Poorten, Vincent Nuyts, Sandra Hermans, Robert Casteels, Ingele Clement, Paul M.J. Case Rep Oncol Case Report A 68-year-old man presented with rapid progressive visual loss caused by a progressive local invasive sinonasal intestinal-type adenocarcinoma (ITAC) with intracranial invasion. The local relapse of ITAC in the ethmoid sinus was previously treated with palliative radiotherapy and carboplatin-paclitaxel, without response, hence disease progression was seen. Ophthalmological examination revealed irreversible blindness of the left eye and a dramatic progressive visual loss of the right eye. Due to important visual loss caused by optic nerve invasion, a palliative treatment with cisplatin-5-fluorouracyl was started. This therapy resulted in a good clinical response with a regression of the local mass and a partial recovery of the vision. S. Karger AG 2019-03-29 /pmc/articles/PMC6489020/ /pubmed/31097936 http://dx.doi.org/10.1159/000499602 Text en Copyright © 2019 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Claus, Jonas
Jorissen, Mark
Vander Poorten, Vincent
Nuyts, Sandra
Hermans, Robert
Casteels, Ingele
Clement, Paul M.J.
Clinically Relevant Response to Cisplatin-5-Fluorouracyl in Intestinal-Type Sinonasal Adenocarcinoma with Loss of Vision: A Case Report
title Clinically Relevant Response to Cisplatin-5-Fluorouracyl in Intestinal-Type Sinonasal Adenocarcinoma with Loss of Vision: A Case Report
title_full Clinically Relevant Response to Cisplatin-5-Fluorouracyl in Intestinal-Type Sinonasal Adenocarcinoma with Loss of Vision: A Case Report
title_fullStr Clinically Relevant Response to Cisplatin-5-Fluorouracyl in Intestinal-Type Sinonasal Adenocarcinoma with Loss of Vision: A Case Report
title_full_unstemmed Clinically Relevant Response to Cisplatin-5-Fluorouracyl in Intestinal-Type Sinonasal Adenocarcinoma with Loss of Vision: A Case Report
title_short Clinically Relevant Response to Cisplatin-5-Fluorouracyl in Intestinal-Type Sinonasal Adenocarcinoma with Loss of Vision: A Case Report
title_sort clinically relevant response to cisplatin-5-fluorouracyl in intestinal-type sinonasal adenocarcinoma with loss of vision: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489020/
https://www.ncbi.nlm.nih.gov/pubmed/31097936
http://dx.doi.org/10.1159/000499602
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