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Silencing long non-coding RNA HOTAIR exerts anti-oncogenic effect on human acute myeloid leukemia via demethylation of HOXA5 by inhibiting Dnmt3b

BACKGROUND: As an aggressive hematological malignancy, acute myeloid leukemia (AML) remains a dismal disease with poor prognosis. Long non-coding RNAs (lncRNAs) have been widely reported to be involved in tumorigenesis of AML. Here, we define an important role of lncRNA HOTAIR in AML in relation to...

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Detalles Bibliográficos
Autores principales:	Wang, Si-Li, Huang, Yun, Su, Rui, Yu, Yong-Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489230/ https://www.ncbi.nlm.nih.gov/pubmed/31168296 http://dx.doi.org/10.1186/s12935-019-0808-z

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