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Inferring cancer dependencies on metabolic genes from large-scale genetic screens

BACKGROUND: Cancer cells reprogram their metabolism to survive and propagate. Thus, targeting metabolic rewiring in tumors is a promising therapeutic strategy. Genome-wide RNAi and CRISPR screens are powerful tools for identifying genes essential for cancer cell proliferation and survival. Integrati...

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Detalles Bibliográficos
Autores principales:	Lagziel, Shoval, Lee, Won Dong, Shlomi, Tomer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489231/ https://www.ncbi.nlm.nih.gov/pubmed/31039782 http://dx.doi.org/10.1186/s12915-019-0654-4

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