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The opposing effects of interferon-beta and oncostatin-M as regulators of cancer stem cell plasticity in triple-negative breast cancer

BACKGROUND: Highly aggressive, metastatic and therapeutically resistant triple-negative breast cancers (TNBCs) are often enriched for cancer stem cells (CSC). Cytokines within the breast tumor microenvironment (TME) influence the CSC state by regulating tumor cell differentiation programs. Two preva...

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Detalles Bibliográficos
Autores principales: Doherty, Mary R., Parvani, Jenny G., Tamagno, Ilaria, Junk, Damian J., Bryson, Benjamin L., Cheon, Hyeon Joo, Stark, George R., Jackson, Mark W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489282/
https://www.ncbi.nlm.nih.gov/pubmed/31036052
http://dx.doi.org/10.1186/s13058-019-1136-x