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Dysbiosis of the Gut Microbiome in Lung Cancer

Lung cancer (LC) is one of the most serious malignant tumors, which has the fastest growing morbidity and mortality worldwide. A role of the lung microbiota in LC pathogenesis has been analyzed, but a comparable role of the gut microbiota has not yet been investigated. In this study, the gut microbi...

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Autores principales: Zhuang, He, Cheng, Liang, Wang, Yao, Zhang, Yu-Kun, Zhao, Man-Fei, Liang, Gong-Da, Zhang, Meng-Chun, Li, Yong-Guo, Zhao, Jing-Bo, Gao, Yi-Na, Zhou, Yu-Jie, Liu, Shu-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489541/
https://www.ncbi.nlm.nih.gov/pubmed/31065547
http://dx.doi.org/10.3389/fcimb.2019.00112
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author Zhuang, He
Cheng, Liang
Wang, Yao
Zhang, Yu-Kun
Zhao, Man-Fei
Liang, Gong-Da
Zhang, Meng-Chun
Li, Yong-Guo
Zhao, Jing-Bo
Gao, Yi-Na
Zhou, Yu-Jie
Liu, Shu-Lin
author_facet Zhuang, He
Cheng, Liang
Wang, Yao
Zhang, Yu-Kun
Zhao, Man-Fei
Liang, Gong-Da
Zhang, Meng-Chun
Li, Yong-Guo
Zhao, Jing-Bo
Gao, Yi-Na
Zhou, Yu-Jie
Liu, Shu-Lin
author_sort Zhuang, He
collection PubMed
description Lung cancer (LC) is one of the most serious malignant tumors, which has the fastest growing morbidity and mortality worldwide. A role of the lung microbiota in LC pathogenesis has been analyzed, but a comparable role of the gut microbiota has not yet been investigated. In this study, the gut microbiota of 30 LC patients and 30 healthy controls were examined via next-generation sequencing of 16S rRNA and analyzed for diversity and biomarkers. We found that there was no decrease in significant microbial diversity (alpha diversity) in LC patients compared to controls (P observed = 0.1422), while the composition (beta diversity) differed significantly between patients and controls (phylum [stress = 0.153], class [stress = 0.16], order [stress = 0.146], family [stress = 0.153]). Controls had a higher abundance of the bacterial phylum Actinobacteria and genus Bifidobacterium, while patients with LC showed elevated levels of Enterococcus. These bacteria were found as possible biomarkers for LC. A decline of normal function of the gut microbiome in LC patients was also observed. These results provide the basic guidance for a systematic, multilayered assessment of the role of the gut microbiome in LC, which has a promising potential for early prevention and targeted intervention.
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spelling pubmed-64895412019-05-07 Dysbiosis of the Gut Microbiome in Lung Cancer Zhuang, He Cheng, Liang Wang, Yao Zhang, Yu-Kun Zhao, Man-Fei Liang, Gong-Da Zhang, Meng-Chun Li, Yong-Guo Zhao, Jing-Bo Gao, Yi-Na Zhou, Yu-Jie Liu, Shu-Lin Front Cell Infect Microbiol Cellular and Infection Microbiology Lung cancer (LC) is one of the most serious malignant tumors, which has the fastest growing morbidity and mortality worldwide. A role of the lung microbiota in LC pathogenesis has been analyzed, but a comparable role of the gut microbiota has not yet been investigated. In this study, the gut microbiota of 30 LC patients and 30 healthy controls were examined via next-generation sequencing of 16S rRNA and analyzed for diversity and biomarkers. We found that there was no decrease in significant microbial diversity (alpha diversity) in LC patients compared to controls (P observed = 0.1422), while the composition (beta diversity) differed significantly between patients and controls (phylum [stress = 0.153], class [stress = 0.16], order [stress = 0.146], family [stress = 0.153]). Controls had a higher abundance of the bacterial phylum Actinobacteria and genus Bifidobacterium, while patients with LC showed elevated levels of Enterococcus. These bacteria were found as possible biomarkers for LC. A decline of normal function of the gut microbiome in LC patients was also observed. These results provide the basic guidance for a systematic, multilayered assessment of the role of the gut microbiome in LC, which has a promising potential for early prevention and targeted intervention. Frontiers Media S.A. 2019-04-18 /pmc/articles/PMC6489541/ /pubmed/31065547 http://dx.doi.org/10.3389/fcimb.2019.00112 Text en Copyright © 2019 Zhuang, Cheng, Wang, Zhang, Zhao, Liang, Zhang, Li, Zhao, Gao, Zhou and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Zhuang, He
Cheng, Liang
Wang, Yao
Zhang, Yu-Kun
Zhao, Man-Fei
Liang, Gong-Da
Zhang, Meng-Chun
Li, Yong-Guo
Zhao, Jing-Bo
Gao, Yi-Na
Zhou, Yu-Jie
Liu, Shu-Lin
Dysbiosis of the Gut Microbiome in Lung Cancer
title Dysbiosis of the Gut Microbiome in Lung Cancer
title_full Dysbiosis of the Gut Microbiome in Lung Cancer
title_fullStr Dysbiosis of the Gut Microbiome in Lung Cancer
title_full_unstemmed Dysbiosis of the Gut Microbiome in Lung Cancer
title_short Dysbiosis of the Gut Microbiome in Lung Cancer
title_sort dysbiosis of the gut microbiome in lung cancer
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489541/
https://www.ncbi.nlm.nih.gov/pubmed/31065547
http://dx.doi.org/10.3389/fcimb.2019.00112
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