Optimization of Fermentation Conditions for Reteplase Expression by Escherichia coli Using Response Surface Methodology

BACKGROUND: Expression of heterologous proteins at large scale is often a challenging job due to plasmid instability, accumulation of acetate and oxidative damage in bioreactors. Therefore, it is necessary to optimize parameters influencing cell growth and expression of recombinant protein. METHODS:...

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Detalles Bibliográficos
Autores principales: Zare, Hamze, Mir Mohammad Sadeghi, Hamid, Akbari, Vajihe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Avicenna Research Institute 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490408/
https://www.ncbi.nlm.nih.gov/pubmed/31057718

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