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Association between Malondialdehyde and Glutathione (L-gamma-Glutamyl-Cysteinyl-Glycine/GSH) Levels on Workers Exposed to Benzene in Indonesia
BACKGROUND: Chemicals that enter the body, especially benzene, will undergo a detoxification process. Unfortunately, at the detoxification process, sometimes benzene can produce free radicals. Free radical oxidation of lipids produces MDA compounds (malondialdehyde). To overcome these free radicals,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Republic of Macedonia
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490478/ https://www.ncbi.nlm.nih.gov/pubmed/31049107 http://dx.doi.org/10.3889/oamjms.2019.246 |
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author | Tualeka, Abdul Rohim Martiana, Tri Ahsan, Ahsan Russeng, Syamsiar S. Meidikayanti, Wulan |
author_facet | Tualeka, Abdul Rohim Martiana, Tri Ahsan, Ahsan Russeng, Syamsiar S. Meidikayanti, Wulan |
author_sort | Tualeka, Abdul Rohim |
collection | PubMed |
description | BACKGROUND: Chemicals that enter the body, especially benzene, will undergo a detoxification process. Unfortunately, at the detoxification process, sometimes benzene can produce free radicals. Free radical oxidation of lipids produces MDA compounds (malondialdehyde). To overcome these free radicals, the body will adapt to produce Glutathione (GSH) enzymes. AIM: The purpose of this study was to analyse the relationship between benzene concentration, MDA levels and glutathione enzymes in Shoe-Maker Home Industry workers exposed to benzene for more than 10 years. METHODS: Measurement of benzene concentration using a gas chromatography-flame ionisation detector (GC-FID). MDA levels used a modified spectrophotometric and GSH method of thiobarbituric acid (TBA) test. RESULT: The results showed that the majority of respondents had benzene concentrations still below the TLV value, mean of MDA levels were 6.94 mg/ml, while GSH was 4.54 mg/ml. Benzene concentration did not have a significant correlation with MDA and glutathione levels, whereas MDA levels had a strong correlation with glutathione levels (p = 0.000; r = -0.947). CONCLUSION: Workers should always use PPE and always eat foods that contain lots of glutathione enzymes such as spinach or broccoli to reduce the impact of free radicals from benzene inhalation. |
format | Online Article Text |
id | pubmed-6490478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Republic of Macedonia |
record_format | MEDLINE/PubMed |
spelling | pubmed-64904782019-05-02 Association between Malondialdehyde and Glutathione (L-gamma-Glutamyl-Cysteinyl-Glycine/GSH) Levels on Workers Exposed to Benzene in Indonesia Tualeka, Abdul Rohim Martiana, Tri Ahsan, Ahsan Russeng, Syamsiar S. Meidikayanti, Wulan Open Access Maced J Med Sci Public Health BACKGROUND: Chemicals that enter the body, especially benzene, will undergo a detoxification process. Unfortunately, at the detoxification process, sometimes benzene can produce free radicals. Free radical oxidation of lipids produces MDA compounds (malondialdehyde). To overcome these free radicals, the body will adapt to produce Glutathione (GSH) enzymes. AIM: The purpose of this study was to analyse the relationship between benzene concentration, MDA levels and glutathione enzymes in Shoe-Maker Home Industry workers exposed to benzene for more than 10 years. METHODS: Measurement of benzene concentration using a gas chromatography-flame ionisation detector (GC-FID). MDA levels used a modified spectrophotometric and GSH method of thiobarbituric acid (TBA) test. RESULT: The results showed that the majority of respondents had benzene concentrations still below the TLV value, mean of MDA levels were 6.94 mg/ml, while GSH was 4.54 mg/ml. Benzene concentration did not have a significant correlation with MDA and glutathione levels, whereas MDA levels had a strong correlation with glutathione levels (p = 0.000; r = -0.947). CONCLUSION: Workers should always use PPE and always eat foods that contain lots of glutathione enzymes such as spinach or broccoli to reduce the impact of free radicals from benzene inhalation. Republic of Macedonia 2019-04-12 /pmc/articles/PMC6490478/ /pubmed/31049107 http://dx.doi.org/10.3889/oamjms.2019.246 Text en Copyright: © 2019 Abdul Rohim Tualeka, Tri Martiana, Ahsan Ahsan, Syamsiar S. Russeng, Wulan Meidikayanti. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). |
spellingShingle | Public Health Tualeka, Abdul Rohim Martiana, Tri Ahsan, Ahsan Russeng, Syamsiar S. Meidikayanti, Wulan Association between Malondialdehyde and Glutathione (L-gamma-Glutamyl-Cysteinyl-Glycine/GSH) Levels on Workers Exposed to Benzene in Indonesia |
title | Association between Malondialdehyde and Glutathione (L-gamma-Glutamyl-Cysteinyl-Glycine/GSH) Levels on Workers Exposed to Benzene in Indonesia |
title_full | Association between Malondialdehyde and Glutathione (L-gamma-Glutamyl-Cysteinyl-Glycine/GSH) Levels on Workers Exposed to Benzene in Indonesia |
title_fullStr | Association between Malondialdehyde and Glutathione (L-gamma-Glutamyl-Cysteinyl-Glycine/GSH) Levels on Workers Exposed to Benzene in Indonesia |
title_full_unstemmed | Association between Malondialdehyde and Glutathione (L-gamma-Glutamyl-Cysteinyl-Glycine/GSH) Levels on Workers Exposed to Benzene in Indonesia |
title_short | Association between Malondialdehyde and Glutathione (L-gamma-Glutamyl-Cysteinyl-Glycine/GSH) Levels on Workers Exposed to Benzene in Indonesia |
title_sort | association between malondialdehyde and glutathione (l-gamma-glutamyl-cysteinyl-glycine/gsh) levels on workers exposed to benzene in indonesia |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490478/ https://www.ncbi.nlm.nih.gov/pubmed/31049107 http://dx.doi.org/10.3889/oamjms.2019.246 |
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