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Association between Malondialdehyde and Glutathione (L-gamma-Glutamyl-Cysteinyl-Glycine/GSH) Levels on Workers Exposed to Benzene in Indonesia

BACKGROUND: Chemicals that enter the body, especially benzene, will undergo a detoxification process. Unfortunately, at the detoxification process, sometimes benzene can produce free radicals. Free radical oxidation of lipids produces MDA compounds (malondialdehyde). To overcome these free radicals,...

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Autores principales: Tualeka, Abdul Rohim, Martiana, Tri, Ahsan, Ahsan, Russeng, Syamsiar S., Meidikayanti, Wulan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Republic of Macedonia 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490478/
https://www.ncbi.nlm.nih.gov/pubmed/31049107
http://dx.doi.org/10.3889/oamjms.2019.246
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author Tualeka, Abdul Rohim
Martiana, Tri
Ahsan, Ahsan
Russeng, Syamsiar S.
Meidikayanti, Wulan
author_facet Tualeka, Abdul Rohim
Martiana, Tri
Ahsan, Ahsan
Russeng, Syamsiar S.
Meidikayanti, Wulan
author_sort Tualeka, Abdul Rohim
collection PubMed
description BACKGROUND: Chemicals that enter the body, especially benzene, will undergo a detoxification process. Unfortunately, at the detoxification process, sometimes benzene can produce free radicals. Free radical oxidation of lipids produces MDA compounds (malondialdehyde). To overcome these free radicals, the body will adapt to produce Glutathione (GSH) enzymes. AIM: The purpose of this study was to analyse the relationship between benzene concentration, MDA levels and glutathione enzymes in Shoe-Maker Home Industry workers exposed to benzene for more than 10 years. METHODS: Measurement of benzene concentration using a gas chromatography-flame ionisation detector (GC-FID). MDA levels used a modified spectrophotometric and GSH method of thiobarbituric acid (TBA) test. RESULT: The results showed that the majority of respondents had benzene concentrations still below the TLV value, mean of MDA levels were 6.94 mg/ml, while GSH was 4.54 mg/ml. Benzene concentration did not have a significant correlation with MDA and glutathione levels, whereas MDA levels had a strong correlation with glutathione levels (p = 0.000; r = -0.947). CONCLUSION: Workers should always use PPE and always eat foods that contain lots of glutathione enzymes such as spinach or broccoli to reduce the impact of free radicals from benzene inhalation.
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spelling pubmed-64904782019-05-02 Association between Malondialdehyde and Glutathione (L-gamma-Glutamyl-Cysteinyl-Glycine/GSH) Levels on Workers Exposed to Benzene in Indonesia Tualeka, Abdul Rohim Martiana, Tri Ahsan, Ahsan Russeng, Syamsiar S. Meidikayanti, Wulan Open Access Maced J Med Sci Public Health BACKGROUND: Chemicals that enter the body, especially benzene, will undergo a detoxification process. Unfortunately, at the detoxification process, sometimes benzene can produce free radicals. Free radical oxidation of lipids produces MDA compounds (malondialdehyde). To overcome these free radicals, the body will adapt to produce Glutathione (GSH) enzymes. AIM: The purpose of this study was to analyse the relationship between benzene concentration, MDA levels and glutathione enzymes in Shoe-Maker Home Industry workers exposed to benzene for more than 10 years. METHODS: Measurement of benzene concentration using a gas chromatography-flame ionisation detector (GC-FID). MDA levels used a modified spectrophotometric and GSH method of thiobarbituric acid (TBA) test. RESULT: The results showed that the majority of respondents had benzene concentrations still below the TLV value, mean of MDA levels were 6.94 mg/ml, while GSH was 4.54 mg/ml. Benzene concentration did not have a significant correlation with MDA and glutathione levels, whereas MDA levels had a strong correlation with glutathione levels (p = 0.000; r = -0.947). CONCLUSION: Workers should always use PPE and always eat foods that contain lots of glutathione enzymes such as spinach or broccoli to reduce the impact of free radicals from benzene inhalation. Republic of Macedonia 2019-04-12 /pmc/articles/PMC6490478/ /pubmed/31049107 http://dx.doi.org/10.3889/oamjms.2019.246 Text en Copyright: © 2019 Abdul Rohim Tualeka, Tri Martiana, Ahsan Ahsan, Syamsiar S. Russeng, Wulan Meidikayanti. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
spellingShingle Public Health
Tualeka, Abdul Rohim
Martiana, Tri
Ahsan, Ahsan
Russeng, Syamsiar S.
Meidikayanti, Wulan
Association between Malondialdehyde and Glutathione (L-gamma-Glutamyl-Cysteinyl-Glycine/GSH) Levels on Workers Exposed to Benzene in Indonesia
title Association between Malondialdehyde and Glutathione (L-gamma-Glutamyl-Cysteinyl-Glycine/GSH) Levels on Workers Exposed to Benzene in Indonesia
title_full Association between Malondialdehyde and Glutathione (L-gamma-Glutamyl-Cysteinyl-Glycine/GSH) Levels on Workers Exposed to Benzene in Indonesia
title_fullStr Association between Malondialdehyde and Glutathione (L-gamma-Glutamyl-Cysteinyl-Glycine/GSH) Levels on Workers Exposed to Benzene in Indonesia
title_full_unstemmed Association between Malondialdehyde and Glutathione (L-gamma-Glutamyl-Cysteinyl-Glycine/GSH) Levels on Workers Exposed to Benzene in Indonesia
title_short Association between Malondialdehyde and Glutathione (L-gamma-Glutamyl-Cysteinyl-Glycine/GSH) Levels on Workers Exposed to Benzene in Indonesia
title_sort association between malondialdehyde and glutathione (l-gamma-glutamyl-cysteinyl-glycine/gsh) levels on workers exposed to benzene in indonesia
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490478/
https://www.ncbi.nlm.nih.gov/pubmed/31049107
http://dx.doi.org/10.3889/oamjms.2019.246
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