Gene-edited babies: What went wrong and what could go wrong

During the second World Summit of Human Gene Editing, Jiankui He presented the gene-editing project that led to the birth of two baby girls with man-made C-C chemokine receptor type 5 (CCR5) mutations. This extremely irresponsible behavior violated the ethical consensus of scientists all over the wo...

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Detalles Bibliográficos
Autores principales: Wang, Haoyi, Yang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490877/
https://www.ncbi.nlm.nih.gov/pubmed/31039144
http://dx.doi.org/10.1371/journal.pbio.3000224
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author Wang, Haoyi
Yang, Hui
author_facet Wang, Haoyi
Yang, Hui
author_sort Wang, Haoyi
collection PubMed
description During the second World Summit of Human Gene Editing, Jiankui He presented the gene-editing project that led to the birth of two baby girls with man-made C-C chemokine receptor type 5 (CCR5) mutations. This extremely irresponsible behavior violated the ethical consensus of scientists all over the world. His presentation revealed a troubling lack not only of basic medical ethics but also of the requisite understanding of genetics and gene editing. Here, we review the rationale and design of his experiment along with the presented data, and provide our scientific criticism of this misconduct.
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spelling pubmed-64908772019-05-17 Gene-edited babies: What went wrong and what could go wrong Wang, Haoyi Yang, Hui PLoS Biol Perspective During the second World Summit of Human Gene Editing, Jiankui He presented the gene-editing project that led to the birth of two baby girls with man-made C-C chemokine receptor type 5 (CCR5) mutations. This extremely irresponsible behavior violated the ethical consensus of scientists all over the world. His presentation revealed a troubling lack not only of basic medical ethics but also of the requisite understanding of genetics and gene editing. Here, we review the rationale and design of his experiment along with the presented data, and provide our scientific criticism of this misconduct. Public Library of Science 2019-04-30 /pmc/articles/PMC6490877/ /pubmed/31039144 http://dx.doi.org/10.1371/journal.pbio.3000224 Text en © 2019 Wang, Yang http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Perspective
Wang, Haoyi
Yang, Hui
Gene-edited babies: What went wrong and what could go wrong
title Gene-edited babies: What went wrong and what could go wrong
title_full Gene-edited babies: What went wrong and what could go wrong
title_fullStr Gene-edited babies: What went wrong and what could go wrong
title_full_unstemmed Gene-edited babies: What went wrong and what could go wrong
title_short Gene-edited babies: What went wrong and what could go wrong
title_sort gene-edited babies: what went wrong and what could go wrong
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490877/
https://www.ncbi.nlm.nih.gov/pubmed/31039144
http://dx.doi.org/10.1371/journal.pbio.3000224
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