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Oscillatory hyperactivity and hyperconnectivity in young APOE-ɛ4 carriers and hypoconnectivity in Alzheimer’s disease

We studied resting-state oscillatory connectivity using magnetoencephalography in healthy young humans (N = 183) genotyped for APOE-ɛ4, the greatest genetic risk for Alzheimer’s disease (AD). Connectivity across frequencies, but most prevalent in alpha/beta, was increased in APOE-ɛ4 in a set of most...

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Autores principales: Koelewijn, Loes, Lancaster, Thomas M, Linden, David, Dima, Diana C, Routley, Bethany C, Magazzini, Lorenzo, Barawi, Kali, Brindley, Lisa, Adams, Rachael, Tansey, Katherine E, Bompas, Aline, Tales, Andrea, Bayer, Antony, Singh, Krish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491037/
https://www.ncbi.nlm.nih.gov/pubmed/31038453
http://dx.doi.org/10.7554/eLife.36011
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author Koelewijn, Loes
Lancaster, Thomas M
Linden, David
Dima, Diana C
Routley, Bethany C
Magazzini, Lorenzo
Barawi, Kali
Brindley, Lisa
Adams, Rachael
Tansey, Katherine E
Bompas, Aline
Tales, Andrea
Bayer, Antony
Singh, Krish
author_facet Koelewijn, Loes
Lancaster, Thomas M
Linden, David
Dima, Diana C
Routley, Bethany C
Magazzini, Lorenzo
Barawi, Kali
Brindley, Lisa
Adams, Rachael
Tansey, Katherine E
Bompas, Aline
Tales, Andrea
Bayer, Antony
Singh, Krish
author_sort Koelewijn, Loes
collection PubMed
description We studied resting-state oscillatory connectivity using magnetoencephalography in healthy young humans (N = 183) genotyped for APOE-ɛ4, the greatest genetic risk for Alzheimer’s disease (AD). Connectivity across frequencies, but most prevalent in alpha/beta, was increased in APOE-ɛ4 in a set of mostly right-hemisphere connections, including lateral parietal and precuneus regions of the Default Mode Network. Similar regions also demonstrated hyperactivity, but only in gamma (40–160 Hz). In a separate study of AD patients, hypoconnectivity was seen in an extended bilateral network that partially overlapped with the hyperconnected regions seen in young APOE-ɛ4 carriers. Using machine-learning, AD patients could be distinguished from elderly controls with reasonable sensitivity and specificity, while young APOE-e4 carriers could also be distinguished from their controls with above chance performance. These results support theories of initial hyperconnectivity driving eventual profound disconnection in AD and suggest that this is present decades before the onset of AD symptomology.
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spelling pubmed-64910372019-05-01 Oscillatory hyperactivity and hyperconnectivity in young APOE-ɛ4 carriers and hypoconnectivity in Alzheimer’s disease Koelewijn, Loes Lancaster, Thomas M Linden, David Dima, Diana C Routley, Bethany C Magazzini, Lorenzo Barawi, Kali Brindley, Lisa Adams, Rachael Tansey, Katherine E Bompas, Aline Tales, Andrea Bayer, Antony Singh, Krish eLife Neuroscience We studied resting-state oscillatory connectivity using magnetoencephalography in healthy young humans (N = 183) genotyped for APOE-ɛ4, the greatest genetic risk for Alzheimer’s disease (AD). Connectivity across frequencies, but most prevalent in alpha/beta, was increased in APOE-ɛ4 in a set of mostly right-hemisphere connections, including lateral parietal and precuneus regions of the Default Mode Network. Similar regions also demonstrated hyperactivity, but only in gamma (40–160 Hz). In a separate study of AD patients, hypoconnectivity was seen in an extended bilateral network that partially overlapped with the hyperconnected regions seen in young APOE-ɛ4 carriers. Using machine-learning, AD patients could be distinguished from elderly controls with reasonable sensitivity and specificity, while young APOE-e4 carriers could also be distinguished from their controls with above chance performance. These results support theories of initial hyperconnectivity driving eventual profound disconnection in AD and suggest that this is present decades before the onset of AD symptomology. eLife Sciences Publications, Ltd 2019-04-30 /pmc/articles/PMC6491037/ /pubmed/31038453 http://dx.doi.org/10.7554/eLife.36011 Text en © 2019, Koelewijn et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Koelewijn, Loes
Lancaster, Thomas M
Linden, David
Dima, Diana C
Routley, Bethany C
Magazzini, Lorenzo
Barawi, Kali
Brindley, Lisa
Adams, Rachael
Tansey, Katherine E
Bompas, Aline
Tales, Andrea
Bayer, Antony
Singh, Krish
Oscillatory hyperactivity and hyperconnectivity in young APOE-ɛ4 carriers and hypoconnectivity in Alzheimer’s disease
title Oscillatory hyperactivity and hyperconnectivity in young APOE-ɛ4 carriers and hypoconnectivity in Alzheimer’s disease
title_full Oscillatory hyperactivity and hyperconnectivity in young APOE-ɛ4 carriers and hypoconnectivity in Alzheimer’s disease
title_fullStr Oscillatory hyperactivity and hyperconnectivity in young APOE-ɛ4 carriers and hypoconnectivity in Alzheimer’s disease
title_full_unstemmed Oscillatory hyperactivity and hyperconnectivity in young APOE-ɛ4 carriers and hypoconnectivity in Alzheimer’s disease
title_short Oscillatory hyperactivity and hyperconnectivity in young APOE-ɛ4 carriers and hypoconnectivity in Alzheimer’s disease
title_sort oscillatory hyperactivity and hyperconnectivity in young apoe-ɛ4 carriers and hypoconnectivity in alzheimer’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491037/
https://www.ncbi.nlm.nih.gov/pubmed/31038453
http://dx.doi.org/10.7554/eLife.36011
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