Cargando…

Gabapentin increases expression of δ subunit-containing GABA(A) receptors

BACKGROUND: Gabapentin is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). Its anticonvulsant, analgesic and anxiolytic properties suggest that it increases GABAergic inhibition; however, the molecular basis for these effects is unknown as gabapentin does not direct...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Jieying, Wang, Dian-Shi, Bonin, Robert P., Penna, Antonello, Alavian-Ghavanini, Ali, Zurek, Agnieszka A., Rauw, Gail, Baker, Glen B., Orser, Beverley A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491385/ https://www.ncbi.nlm.nih.gov/pubmed/30878595 http://dx.doi.org/10.1016/j.ebiom.2019.03.008

Ejemplares similares

Memory Deficits Induced by Inflammation Are Regulated by α5-Subunit-Containing GABA(A) Receptors
por: Wang, Dian-Shi, et al.
Publicado: (2012)

δ-Subunit Containing GABA(A) Receptors Modulate Respiratory Networks
por: Montandon, Gaspard, et al.
Publicado: (2017)

Hyperpolarization-Activated Current (I(h)) Is Reduced in Hippocampal Neurons from Gabra5−/− Mice
por: Bonin, Robert P., et al.
Publicado: (2013)

Stoichiometry of δ subunit containing GABA(A) receptors
por: Patel, B, et al.
Publicado: (2014)

Acutely increasing δGABA(A) receptor activity impairs memory and inhibits synaptic plasticity in the hippocampus
por: Whissell, Paul D., et al.
Publicado: (2013)

Non-neuronal, slow GABA signalling in the ventrobasal thalamus targets δ-subunit-containing GABA(A) receptors
por: Jiménez-González, Cristina, et al.
Publicado: (2011)

δ Subunit-containing GABA(A) receptor prevents overgeneralization of fear in adult mice
por: Zhang, Wen-Hua, et al.
Publicado: (2017)

Pharmacological and Biophysical Characteristics of Picrotoxin-Resistant, δSubunit-Containing GABA(A) Receptors
por: Shu, Hong-Jin, et al.
Publicado: (2021)

α5 Subunit-containing GABA(A) receptors mediate a slowly decaying inhibitory synaptic current in CA1 pyramidal neurons following Schaffer collateral activation
por: Vargas-Caballero, Mariana, et al.
Publicado: (2010)

δ Subunit‐containing GABA(A) receptors are preferred targets for the centrally acting analgesic flupirtine
por: Klinger, Felicia, et al.
Publicado: (2015)

Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABA(A) Receptor Positive Allosteric Modulator
por: Piantadosi, Sean C., et al.
Publicado: (2016)

α5GABA(A) receptor deficiency causes autism‐like behaviors
por: Zurek, Agnieszka A., et al.
Publicado: (2016)

GABA(A) Receptors in Astrocytes Are Targets for Commonly Used Intravenous and Inhalational General Anesthetic Drugs
por: Chung, Woosuk, et al.
Publicado: (2022)

The contribution of δ subunit-containing GABA(A) receptors to phasic and tonic conductance changes in cerebellum, thalamus and neocortex
por: Ye, Zhiwen, et al.
Publicado: (2013)

Cell-surface biotinylation of GABA(A) receptors in mouse hippocampal slices after sevoflurane anesthesia
por: Ariza, Anthony, et al.
Publicado: (2023)

Hold the Gaba: A Case of Gabapentin-induced Hepatotoxicity
por: Jackson, Christopher D, et al.
Publicado: (2018)

Polymorphism and Multi-Component Crystal Formation of GABA and Gabapentin
por: Komisarek, Daniel, et al.
Publicado: (2023)

Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons
por: Ferando, Isabella, et al.
Publicado: (2013)

Identification of transthyretin as a novel interacting partner for the δ subunit of GABA(A) receptors
por: Zhou, Li, et al.
Publicado: (2019)

Direct, gabapentin-insensitive interaction of a soluble form of the calcium channel subunit α(2)δ-1 with thrombospondin-4
por: El-Awaad, Ehab, et al.
Publicado: (2019)

Gabapentin Disrupts Binding of Perlecan to the α(2)δ(1) Voltage Sensitive Calcium Channel Subunit and Impairs Skeletal Mechanosensation
por: Reyes Fernandez, Perla C., et al.
Publicado: (2022)

Protective Effects of Gabapentin on Allodynia and α(2)δ(1)-Subunit of Voltage-dependent Calcium Channel in Spinal Nerve-Ligated Rats
por: Hahm, Tae Soo, et al.
Publicado: (2009)

Editorial: Innovative approaches for assessing and improving perioperative neurocognitive disorders
por: Koch, Susanne, et al.
Publicado: (2022)

Virally-induced expression of GABA(A) receptor δ subunits following their pathological loss reveals their role in regulating GABA(A) receptor assembly
por: Sun, Yu, et al.
Publicado: (2022)

Cerebellum-Specific Deletion of the GABA(A) Receptor δ Subunit Leads to Sex-Specific Disruption of Behavior
por: Rudolph, Stephanie, et al.
Publicado: (2020)

The Emerging Roles of π Subunit-Containing GABA(A) Receptors in Different Cancers
por: JUVALE, Iman Imtiyaz Ahmed, et al.
Publicado: (2021)

Protein Kinase C-Dependent Effects of Neurosteroids on Synaptic GABA(A) Receptor Inhibition Require the δ-Subunit
por: Littlejohn, Erica L., et al.
Publicado: (2021)

Mice Lacking GABA(A) Receptor δ Subunit Have Altered Pharmaco-EEG Responses to Multiple Drugs
por: Grotell, Milo, et al.
Publicado: (2021)

Therapeutic potential of alpha 5 subunit containing GABA(A) receptors in Alzheimer’s disease
por: Kwakowsky, Andrea, et al.
Publicado: (2021)

Reduced excitatory neurotransmission in the hippocampus after inflammation and sevoflurane anaesthesia
por: Khodaei, Shahin, et al.
Publicado: (2023)

Ovarian cycle-linked plasticity of δ-GABA(A) receptor subunits in hippocampal interneurons affects γ oscillations in vivo
por: Barth, Albert M. I., et al.
Publicado: (2014)

15-deoxy-Δ(12,14)-PGJ(2) promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis
por: Koyani, Chintan N., et al.
Publicado: (2014)

Thrombospondin-4 reduces binding affinity of [(3)H]-gabapentin to calcium-channel α(2)δ-1-subunit but does not interact with α(2)δ-1 on the cell-surface when co-expressed
por: Lana, Beatrice, et al.
Publicado: (2016)

α subunits in GABA(A) receptors are dispensable for GABA and diazepam action
por: Wongsamitkul, Nisa, et al.
Publicado: (2017)

A new approach to estimation of the number of central synapse(s) included in the H-reflex
por: Ghavanini, Mohammadreza Alavian, et al.
Publicado: (2005)

GABA(A) Receptors Containing the α2 Subunit Are Critical for Direction-Selective Inhibition in the Retina
por: Auferkorte, Olivia Nicola, et al.
Publicado: (2012)

GABA(A) Receptors Containing ρ1 Subunits Contribute to In Vivo Effects of Ethanol in Mice
por: Blednov, Yuri A., et al.
Publicado: (2014)

Sedating ventilated COVID-19 patients with inhalational anesthetic drugs
por: Orser, Beverley A., et al.
Publicado: (2020)

Presynaptic α(2)δ-2 Calcium Channel Subunits Regulate Postsynaptic GABA(A) Receptor Abundance and Axonal Wiring
por: Geisler, Stefanie, et al.
Publicado: (2019)

Anticonvulsive evaluation of THIP in the murine pentylenetetrazole kindling model: lack of anticonvulsive effect of THIP despite functional δ‐subunit‐containing GABA(A) receptors in dentate gyrus granule cells
por: Simonsen, Charlotte, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_d7udg40hm2dkga5hv6g63bd61b