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Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in Sepsis

BACKGROUND: Sepsis, the most severe form of infection, involves endothelial dysfunction which contributes to organ failure. To improve therapeutic prospects, elucidation of molecular mechanisms underlying endothelial vascular failure is of essence. METHODS: Polymicrobial contamination induced sepsis...

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Detalles Bibliográficos
Autores principales:	Heun, Yvonn, Pircher, Joachim, Czermak, Thomas, Bluem, Philipp, Hupel, Georg, Bohmer, Monica, Kraemer, Bjoern F., Pogoda, Kristin, Pfeifer, Alexander, Woernle, Markus, Ribeiro, Andrea, Hübner, Max, Kreth, Simone, Claus, Ralf A., Weis, Sebastian, Ungelenk, Luisa, Krötz, Florian, Pohl, Ulrich, Mannell, Hanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491420/ https://www.ncbi.nlm.nih.gov/pubmed/30905847 http://dx.doi.org/10.1016/j.ebiom.2019.03.034

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