Mitochondrial dysfunction-mediated decline in angiogenic capacity of endothelial progenitor cells is associated with capillary rarefaction in patients with hypertension via downregulation of CXCR4/JAK2/SIRT5 signaling

BACKGROUND: Hypertensive patients exhibit decline in capillary density and endothelial progenitor cells (EPCs). However, whether capillary rarefaction in hypertension is associated with defect angiogenesis of EPCs remains unknown. We hypothesized that impaired mitochondrial function of late EPCs in...

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Detalles Bibliográficos
Autores principales: Yu, Bing-Bo, Zhi, Hui, Zhang, Xiao-Yu, Liang, Jian-Wen, He, Jiang, Su, Chen, Xia, Wen-Hao, Zhang, Gao-Xing, Tao, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491423/
https://www.ncbi.nlm.nih.gov/pubmed/30904607
http://dx.doi.org/10.1016/j.ebiom.2019.03.031

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