The Structural Dynamics of Engineered β-Lactamases Vary Broadly on Three Timescales yet Sustain Native Function

Understanding the principles of protein dynamics will help guide engineering of protein function: altering protein motions may be a barrier to success or may be an enabling tool for protein engineering. The impact of dynamics on protein function is typically reported over a fraction of the full scop...

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Detalles Bibliográficos
Autores principales: Gobeil, Sophie M. C., Ebert, Maximillian C. C. J. C., Park, Jaeok, Gagné, Donald, Doucet, Nicolas, Berghuis, Albert M., Pleiss, Jürgen, Pelletier, Joelle N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491436/
https://www.ncbi.nlm.nih.gov/pubmed/31040324
http://dx.doi.org/10.1038/s41598-019-42866-8

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