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Association of hemoglobin A1C with circulating metabolites in Dutch with European, African Surinamese and Ghanaian background
BACKGROUND: The prevalence of type 2 diabetes mellitus (T2DM) varies significantly across ethnic groups. A better understanding of the mechanisms underlying the variation in different ethnic groups may help to elucidate the pathophysiology of T2DM. The present work aims to generate a hypothesis rega...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491479/ https://www.ncbi.nlm.nih.gov/pubmed/31040268 http://dx.doi.org/10.1038/s41387-019-0082-0 |
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author | Zhang, Xiang van den Munckhof, Inge C. L. Rutten, Joost H. W. Netea, Mihai G. Groen, Albert K. Zwinderman, Aeilko H. |
author_facet | Zhang, Xiang van den Munckhof, Inge C. L. Rutten, Joost H. W. Netea, Mihai G. Groen, Albert K. Zwinderman, Aeilko H. |
author_sort | Zhang, Xiang |
collection | PubMed |
description | BACKGROUND: The prevalence of type 2 diabetes mellitus (T2DM) varies significantly across ethnic groups. A better understanding of the mechanisms underlying the variation in different ethnic groups may help to elucidate the pathophysiology of T2DM. The present work aims to generate a hypothesis regarding “why do subjects with African background have excess burden of T2DM?”. METHODS: In the current study, we performed metabolite profiling of plasma samples derived from 773 subjects of three ethnic groups (Dutch with European, Ghanaian and African Surinamese background). We performed Bayesian lognormal regression analyses to assess associations between HbA1c and circulating metabolites. RESULTS: Here we show that subjects with African Surinamese and Ghanaian background had similar associations of HbA1c with circulating amino acids and triglyceride-rich lipoproteins as subjects with European background. In contrast, subjects with Ghanaian and African Surinamese background had different associations of HbA1c with acetoacetate, small LDL particle and small HDL particle concentrations, compared to the subjects with European background. CONCLUSIONS: On the basis of the observations, we hypothesize that the excess burden of T2DM in subjects with African background may be due to impaired cholesterol efflux capacity or abnormal cholesterol uptake. |
format | Online Article Text |
id | pubmed-6491479 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-64914792019-05-01 Association of hemoglobin A1C with circulating metabolites in Dutch with European, African Surinamese and Ghanaian background Zhang, Xiang van den Munckhof, Inge C. L. Rutten, Joost H. W. Netea, Mihai G. Groen, Albert K. Zwinderman, Aeilko H. Nutr Diabetes Article BACKGROUND: The prevalence of type 2 diabetes mellitus (T2DM) varies significantly across ethnic groups. A better understanding of the mechanisms underlying the variation in different ethnic groups may help to elucidate the pathophysiology of T2DM. The present work aims to generate a hypothesis regarding “why do subjects with African background have excess burden of T2DM?”. METHODS: In the current study, we performed metabolite profiling of plasma samples derived from 773 subjects of three ethnic groups (Dutch with European, Ghanaian and African Surinamese background). We performed Bayesian lognormal regression analyses to assess associations between HbA1c and circulating metabolites. RESULTS: Here we show that subjects with African Surinamese and Ghanaian background had similar associations of HbA1c with circulating amino acids and triglyceride-rich lipoproteins as subjects with European background. In contrast, subjects with Ghanaian and African Surinamese background had different associations of HbA1c with acetoacetate, small LDL particle and small HDL particle concentrations, compared to the subjects with European background. CONCLUSIONS: On the basis of the observations, we hypothesize that the excess burden of T2DM in subjects with African background may be due to impaired cholesterol efflux capacity or abnormal cholesterol uptake. Nature Publishing Group UK 2019-04-30 /pmc/articles/PMC6491479/ /pubmed/31040268 http://dx.doi.org/10.1038/s41387-019-0082-0 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Zhang, Xiang van den Munckhof, Inge C. L. Rutten, Joost H. W. Netea, Mihai G. Groen, Albert K. Zwinderman, Aeilko H. Association of hemoglobin A1C with circulating metabolites in Dutch with European, African Surinamese and Ghanaian background |
title | Association of hemoglobin A1C with circulating metabolites in Dutch with European, African Surinamese and Ghanaian background |
title_full | Association of hemoglobin A1C with circulating metabolites in Dutch with European, African Surinamese and Ghanaian background |
title_fullStr | Association of hemoglobin A1C with circulating metabolites in Dutch with European, African Surinamese and Ghanaian background |
title_full_unstemmed | Association of hemoglobin A1C with circulating metabolites in Dutch with European, African Surinamese and Ghanaian background |
title_short | Association of hemoglobin A1C with circulating metabolites in Dutch with European, African Surinamese and Ghanaian background |
title_sort | association of hemoglobin a1c with circulating metabolites in dutch with european, african surinamese and ghanaian background |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491479/ https://www.ncbi.nlm.nih.gov/pubmed/31040268 http://dx.doi.org/10.1038/s41387-019-0082-0 |
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