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Targeting GPER1 to suppress autophagy as a male-specific therapeutic strategy for iron-induced striatal injury
The functional outcome of intracerebral hemorrhage (ICH) in young male patients are poor than in premenopausal women. After ICH, ferrous iron accumulation causes a higher level of oxidative injury associated with autophagic cell death in striatum of male mice than in females. In rodent model of ferr...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491488/ https://www.ncbi.nlm.nih.gov/pubmed/31040364 http://dx.doi.org/10.1038/s41598-019-43244-0 |