Intra-Familial Phenotypic Heterogeneity and Telomere Abnormality in von Hippel- Lindau Disease: Implications for Personalized Surveillance Plan and Pathogenesis of VHL-Associated Tumors

von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome with poor survival. The current recommendations have proposed uniform surveillance strategies for all patients, neglecting the obvious phenotypic varieties. In this study, we aim to confirm the phenotypic heterogeneity in VHL disease an...

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Detalles Bibliográficos
Autores principales: Wang, Jiangyi, Peng, Xiang, Chen, Cen, Ning, Xianghui, Peng, Shuanghe, Li, Teng, Liu, Shengjie, Hong, Baoan, Zhou, Jingcheng, Ma, Kaifang, Cai, Lin, Gong, Kan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491623/
https://www.ncbi.nlm.nih.gov/pubmed/31068970
http://dx.doi.org/10.3389/fgene.2019.00358

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