A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions

BACKGROUND: Activation of brain insulin receptors modulates reward sensitivity, inhibitory control and memory. Variations in the functioning of this mechanism likely associate with individual differences in the risk for related mental disorders (attention deficit hyperactivity disorder or ADHD, addi...

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Detalles Bibliográficos
Autores principales: Hari Dass, Shantala A., McCracken, Kathryn, Pokhvisneva, Irina, Chen, Lawrence M., Garg, Elika, Nguyen, Thao T.T., Wang, Zihan, Barth, Barbara, Yaqubi, Moein, McEwen, Lisa M., MacIsaac, Julie L., Diorio, Josie, Kobor, Michael S., O'Donnell, Kieran J., Meaney, Michael J., Silveira, Patricia P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491717/
https://www.ncbi.nlm.nih.gov/pubmed/30922963
http://dx.doi.org/10.1016/j.ebiom.2019.03.051

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