Application of in vitro Drug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP)

Currently no approved treatment exists for fibrodysplasia ossificans progressiva (FOP) patients, and disease progression results in severe restriction of joint function and premature mortality. LDN-193189 has been demonstrated to be efficacious in a mouse FOP disease model after oral administration....

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Detalles Bibliográficos
Autores principales: Padilha, Elias C., Wang, Jianyao, Kerns, Ed, Lee, Arthur, Huang, Wenwei, Jiang, Jian-kang, McKew, John, Mutlib, Abdul, Peccinini, Rosangela G., Yu, Paul B., Sanderson, Philip, Xu, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491728/
https://www.ncbi.nlm.nih.gov/pubmed/31068801
http://dx.doi.org/10.3389/fphar.2019.00234

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