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Ultrasound for Breast Cancer Screening in High-Risk Women: Results From a Population-Based Cancer Screening Program in China

Background: Ultrasound is an important modality for breast cancer screening. However, the evidence on the effectiveness of ultrasound screening in population-based cancer screening program in lacking. We aimed to evaluate the diagnostic yield of ultrasound screening in a population-based breast canc...

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Autores principales: Wang, Yong, Chen, Hongda, Li, Ni, Ren, Jiansong, Zhang, Kai, Dai, Min, He, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491776/
https://www.ncbi.nlm.nih.gov/pubmed/31069168
http://dx.doi.org/10.3389/fonc.2019.00286
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author Wang, Yong
Chen, Hongda
Li, Ni
Ren, Jiansong
Zhang, Kai
Dai, Min
He, Jie
author_facet Wang, Yong
Chen, Hongda
Li, Ni
Ren, Jiansong
Zhang, Kai
Dai, Min
He, Jie
author_sort Wang, Yong
collection PubMed
description Background: Ultrasound is an important modality for breast cancer screening. However, the evidence on the effectiveness of ultrasound screening in population-based cancer screening program in lacking. We aimed to evaluate the diagnostic yield of ultrasound screening in a population-based breast cancer screening in China. Methods: The analyses were conducted in the context of the Cancer Screening Program in Urban China, which recruited 1,938,996 eligible participants aged 40–69 years from 16 provinces in China from 2012 to 2016. We included 72,250 women assessed to be high-risk for breast cancer who undertook ultrasound screening per study protocol. Diagnostic yield according to the Breast Imaging Reporting and Data System (BI-RADS) was evaluated. Risk factors associated with the positive findings of ultrasound were also explored by univariate and multivariable logistic regression analyses. Results: Overall, there were 9,765 (13.51%) women had positive findings of ultrasound screening, including 8,487 (11.75%), 1,210 (1.67%), and 68 (0.09%) of BI-RADS categories of III, IV, and V, respectively. Younger ages, late age of 1st live birth and short-term breast feeding were found to be positively associated with positive findings under ultrasound in multivariate analyses stratified by menopause status and family history of breast cancer. Multivariable prediction models were constructed and yielded only modest prediction accuracy, with AUCs around 0.55. Conclusions: We found the diagnostic yield of ultrasound screening for breast cancer in high-risk population was satisfactory. Prediction models based on environmental risk factors had limited prediction accuracy and need to be improved in the future.
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spelling pubmed-64917762019-05-08 Ultrasound for Breast Cancer Screening in High-Risk Women: Results From a Population-Based Cancer Screening Program in China Wang, Yong Chen, Hongda Li, Ni Ren, Jiansong Zhang, Kai Dai, Min He, Jie Front Oncol Oncology Background: Ultrasound is an important modality for breast cancer screening. However, the evidence on the effectiveness of ultrasound screening in population-based cancer screening program in lacking. We aimed to evaluate the diagnostic yield of ultrasound screening in a population-based breast cancer screening in China. Methods: The analyses were conducted in the context of the Cancer Screening Program in Urban China, which recruited 1,938,996 eligible participants aged 40–69 years from 16 provinces in China from 2012 to 2016. We included 72,250 women assessed to be high-risk for breast cancer who undertook ultrasound screening per study protocol. Diagnostic yield according to the Breast Imaging Reporting and Data System (BI-RADS) was evaluated. Risk factors associated with the positive findings of ultrasound were also explored by univariate and multivariable logistic regression analyses. Results: Overall, there were 9,765 (13.51%) women had positive findings of ultrasound screening, including 8,487 (11.75%), 1,210 (1.67%), and 68 (0.09%) of BI-RADS categories of III, IV, and V, respectively. Younger ages, late age of 1st live birth and short-term breast feeding were found to be positively associated with positive findings under ultrasound in multivariate analyses stratified by menopause status and family history of breast cancer. Multivariable prediction models were constructed and yielded only modest prediction accuracy, with AUCs around 0.55. Conclusions: We found the diagnostic yield of ultrasound screening for breast cancer in high-risk population was satisfactory. Prediction models based on environmental risk factors had limited prediction accuracy and need to be improved in the future. Frontiers Media S.A. 2019-04-24 /pmc/articles/PMC6491776/ /pubmed/31069168 http://dx.doi.org/10.3389/fonc.2019.00286 Text en Copyright © 2019 Wang, Chen, Li, Ren, Zhang, Dai and He. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wang, Yong
Chen, Hongda
Li, Ni
Ren, Jiansong
Zhang, Kai
Dai, Min
He, Jie
Ultrasound for Breast Cancer Screening in High-Risk Women: Results From a Population-Based Cancer Screening Program in China
title Ultrasound for Breast Cancer Screening in High-Risk Women: Results From a Population-Based Cancer Screening Program in China
title_full Ultrasound for Breast Cancer Screening in High-Risk Women: Results From a Population-Based Cancer Screening Program in China
title_fullStr Ultrasound for Breast Cancer Screening in High-Risk Women: Results From a Population-Based Cancer Screening Program in China
title_full_unstemmed Ultrasound for Breast Cancer Screening in High-Risk Women: Results From a Population-Based Cancer Screening Program in China
title_short Ultrasound for Breast Cancer Screening in High-Risk Women: Results From a Population-Based Cancer Screening Program in China
title_sort ultrasound for breast cancer screening in high-risk women: results from a population-based cancer screening program in china
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491776/
https://www.ncbi.nlm.nih.gov/pubmed/31069168
http://dx.doi.org/10.3389/fonc.2019.00286
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