Suppression of Conditional TDP-43 Transgene Expression Differentially Affects Early Cognitive and Social Phenotypes in TDP-43 Mice

Dysregulation of TAR DNA-binding protein 43 (TDP-43) is a hallmark feature of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), two fatal neurodegenerative diseases. TDP-43 is a ubiquitously expressed RNA-binding protein with many physiological functions, playing a role in multi...

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Detalles Bibliográficos
Autores principales: Silva, Pablo R., Nieva, Gabriela V., Igaz, Lionel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491777/
https://www.ncbi.nlm.nih.gov/pubmed/31068973
http://dx.doi.org/10.3389/fgene.2019.00369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491777/
https://www.ncbi.nlm.nih.gov/pubmed/31068973
http://dx.doi.org/10.3389/fgene.2019.00369

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