Scurfy Mice Develop Features of Connective Tissue Disease Overlap Syndrome and Mixed Connective Tissue Disease in the Absence of Regulatory T Cells

Due to a missense mutation in the Foxp3 gene, scurfy mice are deficient in functional regulatory T cells (Treg). The consequent loss of peripheral tolerance manifests itself by fatal autoimmune mediated multi-organ disease. Previous studies have outlined the systemic inflammatory disease and demonst...

Descripción completa

Detalles Bibliográficos
Autores principales: Yilmaz, Osman K., Haeberle, Stefanie, Zhang, Meifeng, Fritzler, Marvin J., Enk, Alexander H., Hadaschik, Eva N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491778/
https://www.ncbi.nlm.nih.gov/pubmed/31068947
http://dx.doi.org/10.3389/fimmu.2019.00881

Ejemplares similares

Ejemplares similares