Alternative splicing of the tumor suppressor ASPP2 results in a stress-inducible, oncogenic isoform prevalent in acute leukemia

BACKGROUND: Apoptosis-stimulating Protein of TP53-2 (ASPP2) is a tumor suppressor enhancing TP53-mediated apoptosis via binding to the TP53 core domain. TP53 mutations found in cancers disrupt ASPP2 binding, arguing for an important role of ASPP2 in TP53-mediated tumor suppression. We now identify a...

Descripción completa

Detalles Bibliográficos
Autores principales: Schittenhelm, Marcus Matthias, Walter, Bianca, Tsintari, Vasileia, Federmann, Birgit, Bajrami Saipi, Mihada, Akmut, Figen, Illing, Barbara, Mau-Holzmann, Ulrike, Fend, Falko, Lopez, Charles Darin, Kampa-Schittenhelm, Kerstin Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491939/
https://www.ncbi.nlm.nih.gov/pubmed/30952616
http://dx.doi.org/10.1016/j.ebiom.2019.03.028

Ejemplares similares

Ejemplares similares