Cyclosporine A sensitizes lung cancer cells to crizotinib through inhibition of the Ca2(+)/calcineurin/Erk pathway

BACKGROUND: Crizotinib has potent anti-tumor activity in patients with advanced MET-amplified non-small cell lung cancer (NSCLC). However, the therapeutic effect is still not satisfying. Thus, developing approaches that improve the efficacy of crizotinib remains a significant challenge. METHODS: MET...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Zhen, Jiang, Liming, Li, Yiran, Xie, Binbin, Xie, Jiansheng, Wang, Zhanggui, Zhou, Xiaoyun, Jiang, Hanliang, Fang, Yong, Pan, Hongming, Han, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491942/
https://www.ncbi.nlm.nih.gov/pubmed/30879923
http://dx.doi.org/10.1016/j.ebiom.2019.03.019

Ejemplares similares

Ejemplares similares