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Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores

In living cells, redox chains rely on nanoconfinement using tiny enclosures, such as the mitochondrial matrix or chloroplast stroma, to concentrate enzymes and limit distances that nicotinamide cofactors and other metabolites must diffuse. In a chemical analogue exploiting this principle, nicotinami...

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Detalles Bibliográficos
Autores principales: Megarity, Clare F., Siritanaratkul, Bhavin, Heath, Rachel S., Wan, Lei, Morello, Giorgio, FitzPatrick, Sarah R., Booth, Rosalind L., Sills, Adam J., Robertson, Alexander W., Warner, Jamie H., Turner, Nicholas J., Armstrong, Fraser A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491978/
https://www.ncbi.nlm.nih.gov/pubmed/30633837
http://dx.doi.org/10.1002/anie.201814370
Descripción
Sumario:In living cells, redox chains rely on nanoconfinement using tiny enclosures, such as the mitochondrial matrix or chloroplast stroma, to concentrate enzymes and limit distances that nicotinamide cofactors and other metabolites must diffuse. In a chemical analogue exploiting this principle, nicotinamide adenine dinucleotide phosphate (NADPH) and NADP(+) are cycled rapidly between ferredoxin–NADP(+) reductase and a second enzyme—the pairs being juxtaposed within the 5–100 nm scale pores of an indium tin oxide electrode. The resulting electrode material, denoted (FNR+E2)@ITO/support, can drive and exploit a potentially large number of enzyme‐catalysed reactions.