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Inhibition of SIRT2 by Targeting GSK3β-Mediated Phosphorylation Alleviates SIRT2 Toxicity in SH-SY5Y Cells

Sirtuin 2 (SIRT2) is thought to be important in the pathogenesis of Parkinson’s disease (PD), and the inhibition of SIRT2 rescues α-synuclein toxicity in a cellular model of PD. Recent studies have focused on identifying inhibitors of SIRT2, but little is known about the processes that directly regu...

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Detalles Bibliográficos
Autores principales:	Liu, Shuhu, Zhou, Zhihua, Zhang, Ling, Meng, Siying, Li, Shuji, Wang, Xuemin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492038/ https://www.ncbi.nlm.nih.gov/pubmed/31105527 http://dx.doi.org/10.3389/fncel.2019.00148

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