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Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative
The International Council on Harmonization (ICH) S7B and E14 regulatory guidelines are sensitive but not specific for predicting which drugs are pro‐arrhythmic. In response, the Comprehensive In Vitro Proarrhythmia Assay (CiPA) was proposed that integrates multi‐ion channel pharmacology data in vitr...
Autores principales: | Li, Zhihua, Ridder, Bradley J., Han, Xiaomei, Wu, Wendy W., Sheng, Jiansong, Tran, Phu N., Wu, Min, Randolph, Aaron, Johnstone, Ross H., Mirams, Gary R., Kuryshev, Yuri, Kramer, James, Wu, Caiyun, Crumb, William J., Strauss, David G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492074/ https://www.ncbi.nlm.nih.gov/pubmed/30151907 http://dx.doi.org/10.1002/cpt.1184 |
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