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Engineering synucleinopathy‐resistant human dopaminergic neurons by CRISPR‐mediated deletion of the SNCA gene

An emerging treatment for Parkinson's disease (PD) is cell replacement therapy. Authentic midbrain dopaminergic (mDA) neuronal precursors can be differentiated from human embryonic stem cells (hESCs) and human induced pluripotent stem cells (iPSCs). These laboratory‐generated mDA cells have bee...

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Detalles Bibliográficos
Autores principales:	Chen, Yixi, Dolt, Karamjit Singh, Kriek, Marco, Baker, Terry, Downey, Patrick, Drummond, Nicola J., Canham, Maurice A., Natalwala, Ammar, Rosser, Susan, Kunath, Tilo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Tom Isaacs Special Issue
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492083/ https://www.ncbi.nlm.nih.gov/pubmed/30472757 http://dx.doi.org/10.1111/ejn.14286

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