Rhodium(III)-Catalyzed Intramolecular Annulations of Acrylic and Benzoic Acids to Alkynes

[Image: see text] Rh(III) catalysts can promote a formal (4 + 2) intramolecular oxidative annulation between acrylic or benzoic acid derivatives and alkynes. The reaction, which involves a C–H activation process, allows for a rapid assembly of appealing bicyclic pyran-2-ones and tricyclic isocoumari...

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Autores principales: F. Fernández, David, Casanova, Noelia, Mascareñas, José Luis, Gulías, Moisés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492232/
https://www.ncbi.nlm.nih.gov/pubmed/31058249
http://dx.doi.org/10.1021/acsomega.9b00022
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author F. Fernández, David
Casanova, Noelia
Mascareñas, José Luis
Gulías, Moisés
author_facet F. Fernández, David
Casanova, Noelia
Mascareñas, José Luis
Gulías, Moisés
author_sort F. Fernández, David
collection PubMed
description [Image: see text] Rh(III) catalysts can promote a formal (4 + 2) intramolecular oxidative annulation between acrylic or benzoic acid derivatives and alkynes. The reaction, which involves a C–H activation process, allows for a rapid assembly of appealing bicyclic pyran-2-ones and tricyclic isocoumarin derivatives in moderate to good yields. The α-pyrone moiety of the products provides for further manipulations to obtain relatively complex cyclic skeletons in a very simple manner.
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spelling pubmed-64922322019-05-02 Rhodium(III)-Catalyzed Intramolecular Annulations of Acrylic and Benzoic Acids to Alkynes F. Fernández, David Casanova, Noelia Mascareñas, José Luis Gulías, Moisés ACS Omega [Image: see text] Rh(III) catalysts can promote a formal (4 + 2) intramolecular oxidative annulation between acrylic or benzoic acid derivatives and alkynes. The reaction, which involves a C–H activation process, allows for a rapid assembly of appealing bicyclic pyran-2-ones and tricyclic isocoumarin derivatives in moderate to good yields. The α-pyrone moiety of the products provides for further manipulations to obtain relatively complex cyclic skeletons in a very simple manner. American Chemical Society 2019-04-04 /pmc/articles/PMC6492232/ /pubmed/31058249 http://dx.doi.org/10.1021/acsomega.9b00022 Text en Copyright © 2019 American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
spellingShingle F. Fernández, David
Casanova, Noelia
Mascareñas, José Luis
Gulías, Moisés
Rhodium(III)-Catalyzed Intramolecular Annulations of Acrylic and Benzoic Acids to Alkynes
title Rhodium(III)-Catalyzed Intramolecular Annulations of Acrylic and Benzoic Acids to Alkynes
title_full Rhodium(III)-Catalyzed Intramolecular Annulations of Acrylic and Benzoic Acids to Alkynes
title_fullStr Rhodium(III)-Catalyzed Intramolecular Annulations of Acrylic and Benzoic Acids to Alkynes
title_full_unstemmed Rhodium(III)-Catalyzed Intramolecular Annulations of Acrylic and Benzoic Acids to Alkynes
title_short Rhodium(III)-Catalyzed Intramolecular Annulations of Acrylic and Benzoic Acids to Alkynes
title_sort rhodium(iii)-catalyzed intramolecular annulations of acrylic and benzoic acids to alkynes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492232/
https://www.ncbi.nlm.nih.gov/pubmed/31058249
http://dx.doi.org/10.1021/acsomega.9b00022
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