The structure of the Shiga toxin 2a A‐subunit dictates the interactions of the toxin with blood components

Hemolytic uremic syndrome (eHUS) is a severe complication of human infections with Shiga toxins (Stxs)‐producing Escherichia coli. A key step in the pathogenesis of eHUS is the interaction of Stxs with blood components before the targeting of renal endothelial cells. Here, we show that a single prot...

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Detalles Bibliográficos
Autores principales: Brigotti, Maurizio, Orth‐Höller, Dorothea, Carnicelli, Domenica, Porcellini, Elisa, Galassi, Elisabetta, Tazzari, Pier Luigi, Ricci, Francesca, Manoli, Francesco, Manet, Ilse, Talasz, Heribert, Lindner, Herbert H., Speth, Cornelia, Erbeznik, Thomas, Fuchs, Stefan, Posch, Wilfried, Chatterjee, Sneha, Würzner, Reinhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492301/
https://www.ncbi.nlm.nih.gov/pubmed/30578712
http://dx.doi.org/10.1111/cmi.13000

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