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The Differentiation of Soft Tissue Infiltration and Surrounding Edema in an Animal Model of Malignant Bone Tumor: Evaluation by Dual-Energy CT

To study the value of dual energy computed tomography in distinguishing soft tissue infiltration from surrounding soft tissue edema in rabbit malignant bone tumor, a malignant bone tumor model was established through implantation of VX2 tumor fragments into the tibiae of rabbits. Tumor adjacent soft...

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Detalles Bibliográficos
Autores principales: Chen, Haisong, Zhang, Yuan, Pang, Jing, Wu, Zengjie, Jia, Meng, Dong, Qian, Xu, Wenjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492347/
https://www.ncbi.nlm.nih.gov/pubmed/31035867
http://dx.doi.org/10.1177/1533033819846842
Descripción
Sumario:To study the value of dual energy computed tomography in distinguishing soft tissue infiltration from surrounding soft tissue edema in rabbit malignant bone tumor, a malignant bone tumor model was established through implantation of VX2 tumor fragments into the tibiae of rabbits. Tumor adjacent soft tissues were divided into 3 areas according to pathology and computed tomography images. Computed tomography spectral curve slopes and iodine and water concentrations were assessed. Statistical analyses were performed using the Mann-Whitney U test and t test. The spectral curve of the soft tissue infiltration areas has a slope (1.30 ± 0.41) higher than that of the soft tissue edema areas (0.71 ± 0.23; P < .001). The iodine concentration in the soft tissue infiltration areas (8.56 ± 2.15) was higher than that in the in soft tissue edema areas (6.09 ± 1.02; P < .001). Water concentration was similar in the soft tissue infiltration areas (1033.86 ± 10.50) to that of the edema areas (1031.45 ± 12.83; P < .05). Spectral curve analysis and iodine–water concentration are helpful in the differentiation of bone tumor soft tissue infiltration and soft tissue edema.