Epigenome-wide association study for lifetime estrogen exposure identifies an epigenetic signature associated with breast cancer risk

BACKGROUND: It is well established that estrogens and other hormonal factors influence breast cancer susceptibility. We hypothesized that a woman’s total lifetime estrogen exposure accumulates changes in DNA methylation, detectable in the blood, which could be used in risk assessment for breast canc...

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Detalles Bibliográficos
Autores principales: Johansson, Annelie, Palli, Domenico, Masala, Giovanna, Grioni, Sara, Agnoli, Claudia, Tumino, Rosario, Giurdanella, Maria Concetta, Fasanelli, Francesca, Sacerdote, Carlotta, Panico, Salvatore, Mattiello, Amalia, Polidoro, Silvia, Jones, Michael E., Schoemaker, Minouk J., Orr, Nick, Tomczyk, Katarzyna, Johnson, Nichola, Fletcher, Olivia, Perduca, Vittorio, Baglietto, Laura, Dugué, Pierre-Antoine, Southey, Melissa C., Giles, Graham G., English, Dallas R., Milne, Roger L., Severi, Gianluca, Ambatipudi, Srikant, Cuenin, Cyrille, Chajès, Veronique, Romieu, Isabelle, Herceg, Zdenko, Swerdlow, Anthony J., Vineis, Paolo, Flanagan, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492393/
https://www.ncbi.nlm.nih.gov/pubmed/31039828
http://dx.doi.org/10.1186/s13148-019-0664-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492393/
https://www.ncbi.nlm.nih.gov/pubmed/31039828
http://dx.doi.org/10.1186/s13148-019-0664-7

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