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Ascites from ovarian cancer patients stimulates MUC16 mucin expression and secretion in human peritoneal mesothelial cells through an Akt-dependent pathway

BACKGROUND: CA125 is a well-established ovarian cancer (OC) serum biomarker. The CA125 heavily glycosylated epitope is carried by the MUC16 mucin, a high molecular weight transmembrane mucin. Upon proteolytic cleavage, the extracellular domain of MUC16 is released from the cell surface into malignan...

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Detalles Bibliográficos
Autores principales:	Matte, Isabelle, Garde-Granger, Perrine, Bessette, Paul, Piché, Alain
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492407/ https://www.ncbi.nlm.nih.gov/pubmed/31039761 http://dx.doi.org/10.1186/s12885-019-5611-7

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