Reliable heritability estimation using sparse regularization in ultrahigh dimensional genome-wide association studies

BACKGROUND: Data from genome-wide association studies (GWASs) have been used to estimate the heritability of human complex traits in recent years. Existing methods are based on the linear mixed model, with the assumption that the genetic effects are random variables, which is opposite to the fixed e...

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Detalles Bibliográficos
Autores principales: Li, Xin, Wu, Dongya, Cui, Yue, Liu, Bing, Walter, Henrik, Schumann, Gunter, Li, Chong, Jiang, Tianzi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492418/
https://www.ncbi.nlm.nih.gov/pubmed/31039742
http://dx.doi.org/10.1186/s12859-019-2792-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492418/
https://www.ncbi.nlm.nih.gov/pubmed/31039742
http://dx.doi.org/10.1186/s12859-019-2792-7

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