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Association Between Periodontitis and Cognitive Impairment in Adults: A Systematic Review
Periodontitis is an oral inflammatory disease and may contribute to low-grade systemic inflammation. Based on the contribution of periodontitis to systemic inflammation and the potential role of systemic inflammation in neuroinflammation, many epidemiological studies have investigated a possible ass...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492457/ https://www.ncbi.nlm.nih.gov/pubmed/31105630 http://dx.doi.org/10.3389/fneur.2019.00323 |
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author | Nascimento, Priscila Cunha Castro, Micaele Maria Lopes Magno, Marcela Baraúna Almeida, Anna Paula Costa Ponte Sousa Carvalho Fagundes, Nathália Carolina Fernandes Maia, Lucianne Cople Lima, Rafael Rodrigues |
author_facet | Nascimento, Priscila Cunha Castro, Micaele Maria Lopes Magno, Marcela Baraúna Almeida, Anna Paula Costa Ponte Sousa Carvalho Fagundes, Nathália Carolina Fernandes Maia, Lucianne Cople Lima, Rafael Rodrigues |
author_sort | Nascimento, Priscila Cunha |
collection | PubMed |
description | Periodontitis is an oral inflammatory disease and may contribute to low-grade systemic inflammation. Based on the contribution of periodontitis to systemic inflammation and the potential role of systemic inflammation in neuroinflammation, many epidemiological studies have investigated a possible association between periodontitis and mild cognitive impairment or dementia. The purpose of this study was to evaluate the clinical/epidemiological evidence regarding the association between periodontitis and cognitive decline in adult patients. A search conducted between September and October 2018 was performed in the electronic databases PubMed, Scopus, Web of Science, The Cochrane Library, LILACS, OpenGrey, and Google Scholar, with no publication date or language restrictions. Analytical observational studies in adults (P—Participants), with (E—Exposure) and without periodontitis (C—Comparison) were included in order to determine the association between periodontitis and cognitive decline (O—Outcome). The search identified 509 references, of which eight observational studies were accorded with the eligibility criteria and evaluated. The results should, however, be interpreted cautiously due to the limited number of studies. This systematic review points to the need for further well-designed studies, such as longitudinal observational studies with control of modifiable variables, as diagnostic criteria and time since diagnosis of periodontitis and cognitive impairment, to confirm the proposed association. |
format | Online Article Text |
id | pubmed-6492457 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64924572019-05-17 Association Between Periodontitis and Cognitive Impairment in Adults: A Systematic Review Nascimento, Priscila Cunha Castro, Micaele Maria Lopes Magno, Marcela Baraúna Almeida, Anna Paula Costa Ponte Sousa Carvalho Fagundes, Nathália Carolina Fernandes Maia, Lucianne Cople Lima, Rafael Rodrigues Front Neurol Neurology Periodontitis is an oral inflammatory disease and may contribute to low-grade systemic inflammation. Based on the contribution of periodontitis to systemic inflammation and the potential role of systemic inflammation in neuroinflammation, many epidemiological studies have investigated a possible association between periodontitis and mild cognitive impairment or dementia. The purpose of this study was to evaluate the clinical/epidemiological evidence regarding the association between periodontitis and cognitive decline in adult patients. A search conducted between September and October 2018 was performed in the electronic databases PubMed, Scopus, Web of Science, The Cochrane Library, LILACS, OpenGrey, and Google Scholar, with no publication date or language restrictions. Analytical observational studies in adults (P—Participants), with (E—Exposure) and without periodontitis (C—Comparison) were included in order to determine the association between periodontitis and cognitive decline (O—Outcome). The search identified 509 references, of which eight observational studies were accorded with the eligibility criteria and evaluated. The results should, however, be interpreted cautiously due to the limited number of studies. This systematic review points to the need for further well-designed studies, such as longitudinal observational studies with control of modifiable variables, as diagnostic criteria and time since diagnosis of periodontitis and cognitive impairment, to confirm the proposed association. Frontiers Media S.A. 2019-04-24 /pmc/articles/PMC6492457/ /pubmed/31105630 http://dx.doi.org/10.3389/fneur.2019.00323 Text en Copyright © 2019 Nascimento, Castro, Magno, Almeida, Fagundes, Maia and Lima. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Nascimento, Priscila Cunha Castro, Micaele Maria Lopes Magno, Marcela Baraúna Almeida, Anna Paula Costa Ponte Sousa Carvalho Fagundes, Nathália Carolina Fernandes Maia, Lucianne Cople Lima, Rafael Rodrigues Association Between Periodontitis and Cognitive Impairment in Adults: A Systematic Review |
title | Association Between Periodontitis and Cognitive Impairment in Adults: A Systematic Review |
title_full | Association Between Periodontitis and Cognitive Impairment in Adults: A Systematic Review |
title_fullStr | Association Between Periodontitis and Cognitive Impairment in Adults: A Systematic Review |
title_full_unstemmed | Association Between Periodontitis and Cognitive Impairment in Adults: A Systematic Review |
title_short | Association Between Periodontitis and Cognitive Impairment in Adults: A Systematic Review |
title_sort | association between periodontitis and cognitive impairment in adults: a systematic review |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492457/ https://www.ncbi.nlm.nih.gov/pubmed/31105630 http://dx.doi.org/10.3389/fneur.2019.00323 |
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