Cargando…

Notch-Mediated Tumor-Stroma-Inflammation Networks Promote Invasive Properties and CXCL8 Expression in Triple-Negative Breast Cancer

Stromal cells and pro-inflammatory cytokines play key roles in promoting the aggressiveness of triple-negative breast cancers (TNBC; Basal/Basal-like). In our previous study we demonstrated that stimulation of TNBC and mesenchymal stem cells (MSCs) co-cultures by the pro-inflammatory cytokine tumor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liubomirski, Yulia, Lerrer, Shalom, Meshel, Tsipi, Morein, Dina, Rubinstein-Achiasaf, Linor, Sprinzak, David, Wiemann, Stefan, Körner, Cindy, Ehrlich, Marcelo, Ben-Baruch, Adit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492532/ https://www.ncbi.nlm.nih.gov/pubmed/31105691 http://dx.doi.org/10.3389/fimmu.2019.00804

Ejemplares similares

Tumor-Stroma-Inflammation Networks Promote Pro-metastatic Chemokines and Aggressiveness Characteristics in Triple-Negative Breast Cancer
por: Liubomirski, Yulia, et al.
Publicado: (2019)

Persistent Inflammatory Stimulation Drives the Conversion of MSCs to Inflammatory CAFs That Promote Pro-Metastatic Characteristics in Breast Cancer Cells
por: Rubinstein-Achiasaf, Linor, et al.
Publicado: (2021)

Co-Inflammatory Roles of TGFβ1 in the Presence of TNFα Drive a Pro-inflammatory Fate in Mesenchymal Stem Cells
por: Lerrer, Shalom, et al.
Publicado: (2017)

Continuous Inflammatory Stimulation Leads via Metabolic Plasticity to a Prometastatic Phenotype in Triple-Negative Breast Cancer Cells
por: Morein, Dina, et al.
Publicado: (2021)

Regulation of the inflammatory profile of stromal cells in human breast cancer: prominent roles for TNF-α and the NF-κB pathway
por: Katanov, Christina, et al.
Publicado: (2015)

Notch-Inflammation Networks in Regulation of Breast Cancer Progression
por: Liubomirski, Yulia, et al.
Publicado: (2020)

Inflammation-Driven Breast Tumor Cell Plasticity: Stemness/EMT, Therapy Resistance and Dormancy
por: Baram, Tamir, et al.
Publicado: (2021)

Tumor Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Human Breast Cancer Are Mediated by PD-L1-S283 and Chemokine Axes
por: Erlichman, Nofar, et al.
Publicado: (2022)

Correction: Erlichman et al. Tumor Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Human Breast Cancer Are Mediated by PD-L1-S283 and Chemokine Axes. Cancers 2022, 14, 1042
por: Erlichman, Nofar, et al.
Publicado: (2022)

A Tumor Microenvironment-Driven Network Regulated by STAT3 and p65 Negatively Controls the Enrichment of Cancer Stem Cells in Human HR+/HER2− Breast Cancer
por: Ben-Yaakov, Hagar, et al.
Publicado: (2023)

The inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells
por: Leibovich-Rivkin, Tal, et al.
Publicado: (2014)

Microenvironmental networks promote tumor heterogeneity and enrich for metastatic cancer stem-like cells in Luminal-A breast tumor cells
por: Weitzenfeld, Polina, et al.
Publicado: (2016)

Inflammation-Driven Regulation of PD-L1 and PD-L2, and Their Cross-Interactions with Protective Soluble TNFα Receptors in Human Triple-Negative Breast Cancer
por: Baram, Tamir, et al.
Publicado: (2022)

Progression of Luminal Breast Tumors Is Promoted by Ménage à Trois between the Inflammatory Cytokine TNFα and the Hormonal and Growth-Supporting Arms of the Tumor Microenvironment
por: Weitzenfeld, Polina, et al.
Publicado: (2013)

Tumor-Promoting Circuits That Regulate a Cancer-Related Chemokine Cluster: Dominance of Inflammatory Mediators Over Oncogenic Alterations
por: Leibovich-Rivkin, Tal, et al.
Publicado: (2012)

Breast Cancer: Coordinated Regulation of CCL2 Secretion by Intracellular Glycosaminoglycans and Chemokine Motifs()()
por: Lebel-Haziv, Yaeli, et al.
Publicado: (2014)

Beyond Cell Motility: The Expanding Roles of Chemokines and Their Receptors in Malignancy
por: Morein, Dina, et al.
Publicado: (2020)

miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A
por: Bott, Alexander, et al.
Publicado: (2017)

The Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Breast Cancer Are Regulated by N-Linked Glycosylation-Dependent Activation of STAT3 and STAT1
por: Erlichman, Nofar, et al.
Publicado: (2023)

Chemotherapy Shifts the Balance in Favor of CD8+ TNFR2+ TILs in Triple-Negative Breast Tumors
por: Baram, Tamir, et al.
Publicado: (2021)

Inflammatory mediators in breast cancer: Coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition
por: Soria, Gali, et al.
Publicado: (2011)

Immune checkpoint inhibitors and the shared epitope theory: from hypothesis to practice
por: Lerrer, Shalom, et al.
Publicado: (2019)

Human brain metastatic stroma attracts breast cancer cells via chemokines CXCL16 and CXCL12
por: Chung, Brile, et al.
Publicado: (2017)

Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers
por: Allaoui, Roni, et al.
Publicado: (2016)

Expression of the chemokine CXCL14 in the tumour stroma is an independent marker of survival in breast cancer
por: Sjöberg, Elin, et al.
Publicado: (2016)

Functional Comparison between Endogenous and Synthetic Notch Systems
por: Khamaisi, Bassma, et al.
Publicado: (2022)

Induction of Collagen I by CXCL10 in Ovarian Theca–Stroma Cells via the JNK Pathway
por: Wang, Chaojun, et al.
Publicado: (2022)

Cis-inhibition suppresses basal Notch signaling during sensory organ precursor selection
por: Troost, Tobias, et al.
Publicado: (2023)

Dynamic Ligand Discrimination in the Notch Signaling Pathway
por: Nandagopal, Nagarajan, et al.
Publicado: (2018)

Mutual Inactivation of Notch Receptors and Ligands Facilitates Developmental Patterning
por: Sprinzak, David, et al.
Publicado: (2011)

Tumor-derived CXCL8 signaling augments stroma-derived CCL2-promoted proliferation and CXCL12-mediated invasion of PTEN-deficient prostate cancer cells
por: Maxwell, Pamela J., et al.
Publicado: (2014)

PD-1-stimulated T cell subsets are transcriptionally and functionally distinct
por: Lerrer, Shalom, et al.
Publicado: (2021)

PHOX2B is a suppressor of neuroblastoma metastasis
por: Naftali, Osnat, et al.
Publicado: (2016)

Cell-cell contact area affects Notch signaling and Notch-dependent patterning
por: Shaya, Oren, et al.
Publicado: (2017)

Milking the stroma in triple-negative breast cancer
por: Thompson, Alastair M., et al.
Publicado: (2012)

IP-10/CXCL10 induction in human pancreatic cancer stroma influences lymphocytes recruitment and correlates with poor survival
por: Lunardi, Serena, et al.
Publicado: (2014)

Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states
por: LeBon, Lauren, et al.
Publicado: (2014)

Prognostic impact of CXCL16 and CXCR6 in non-small cell lung cancer: combined high CXCL16 expression in tumor stroma and cancer cells yields improved survival
por: Hald, Sigurd M., et al.
Publicado: (2015)

Correction: Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states
por: LeBon, Lauren, et al.
Publicado: (2014)

MPDZ promotes DLL4-induced Notch signaling during angiogenesis
por: Tetzlaff, Fabian, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_bg5e2abr4244ntrqa5odeic91g