Small molecule ion channels increase host defenses in cystic fibrosis airway epithelia

Loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) compromise epithelial HCO(3)(−) and Cl(−) secretion, reduce airway surface liquid (ASL) pH, and impair respiratory host defenses in people with cystic fibrosis (CF) (1–3). Here we report that apical addition...

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Detalles Bibliográficos
Autores principales: Muraglia, Katrina A., Chorghade, Rajeev S., Kim, Bo Ram, Tang, Xiao Xiao, Shah, Viral S., Grillo, Anthony S., Daniels, Page N., Cioffi, Alexander G., Karp, Philip H., Zhu, Lingyang, Welsh, Michael J., Burke, Martin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492938/
https://www.ncbi.nlm.nih.gov/pubmed/30867598
http://dx.doi.org/10.1038/s41586-019-1018-5

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