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SpCas9-expression by tumor cells can cause T cell-dependent tumor rejection in immunocompetent mice
The CRISPR/Cas9 system has recently emerged as a highly efficient modality in genetic engineering and has been widely considered for various therapeutic applications. However, since the effector protein, SpCas9, has a bacterial origin, its immunogenicity must be explored in further depth. Here, we f...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492962/ https://www.ncbi.nlm.nih.gov/pubmed/31069138 http://dx.doi.org/10.1080/2162402X.2019.1577127 |