Comparative proteomic analysis of human serum before and after liver transplantation using quantitative proteomics

Liver cancer is the second leading cause of cancer mortality worldwide. Safer and more effective diagnostic methods for liver cancer are desirable, and biomarkers represent a potentially alternative method for diagnosis. The present study was designed to identify liver cancer biomarkers. We quantifi...

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Autores principales: Zhang, Ruohan, Ou, Minglin, Zhang, Yue, Yan, Qiang, Chen, Huaizhou, Lai, Liusheng, Li, Ying, Xu, Feilong, Tang, Donge, Sun, Xuyong, Dong, Jianhui, Dai, Yong, Sui, Weiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493459/
https://www.ncbi.nlm.nih.gov/pubmed/31069013
http://dx.doi.org/10.18632/oncotarget.26761
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author Zhang, Ruohan
Ou, Minglin
Zhang, Yue
Yan, Qiang
Chen, Huaizhou
Lai, Liusheng
Li, Ying
Xu, Feilong
Tang, Donge
Sun, Xuyong
Dong, Jianhui
Dai, Yong
Sui, Weiguo
author_facet Zhang, Ruohan
Ou, Minglin
Zhang, Yue
Yan, Qiang
Chen, Huaizhou
Lai, Liusheng
Li, Ying
Xu, Feilong
Tang, Donge
Sun, Xuyong
Dong, Jianhui
Dai, Yong
Sui, Weiguo
author_sort Zhang, Ruohan
collection PubMed
description Liver cancer is the second leading cause of cancer mortality worldwide. Safer and more effective diagnostic methods for liver cancer are desirable, and biomarkers represent a potentially alternative method for diagnosis. The present study was designed to identify liver cancer biomarkers. We quantified the changes in serum protein levels between liver transplantation and healthy (control) females using isobaric tags for relative and absolute quantitation (iTRAQ) as well as proteomic analysis. A total of 1399 proteins were identified; of these, three proteins showed significantly different concentrations between the before transplantation group and the control group. These proteins may thus be relevant to liver cancer and constitute potential liver cancer biomarkers.
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spelling pubmed-64934592019-05-08 Comparative proteomic analysis of human serum before and after liver transplantation using quantitative proteomics Zhang, Ruohan Ou, Minglin Zhang, Yue Yan, Qiang Chen, Huaizhou Lai, Liusheng Li, Ying Xu, Feilong Tang, Donge Sun, Xuyong Dong, Jianhui Dai, Yong Sui, Weiguo Oncotarget Research Paper Liver cancer is the second leading cause of cancer mortality worldwide. Safer and more effective diagnostic methods for liver cancer are desirable, and biomarkers represent a potentially alternative method for diagnosis. The present study was designed to identify liver cancer biomarkers. We quantified the changes in serum protein levels between liver transplantation and healthy (control) females using isobaric tags for relative and absolute quantitation (iTRAQ) as well as proteomic analysis. A total of 1399 proteins were identified; of these, three proteins showed significantly different concentrations between the before transplantation group and the control group. These proteins may thus be relevant to liver cancer and constitute potential liver cancer biomarkers. Impact Journals LLC 2019-04-02 /pmc/articles/PMC6493459/ /pubmed/31069013 http://dx.doi.org/10.18632/oncotarget.26761 Text en Copyright: © 2019 Zhang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Zhang, Ruohan
Ou, Minglin
Zhang, Yue
Yan, Qiang
Chen, Huaizhou
Lai, Liusheng
Li, Ying
Xu, Feilong
Tang, Donge
Sun, Xuyong
Dong, Jianhui
Dai, Yong
Sui, Weiguo
Comparative proteomic analysis of human serum before and after liver transplantation using quantitative proteomics
title Comparative proteomic analysis of human serum before and after liver transplantation using quantitative proteomics
title_full Comparative proteomic analysis of human serum before and after liver transplantation using quantitative proteomics
title_fullStr Comparative proteomic analysis of human serum before and after liver transplantation using quantitative proteomics
title_full_unstemmed Comparative proteomic analysis of human serum before and after liver transplantation using quantitative proteomics
title_short Comparative proteomic analysis of human serum before and after liver transplantation using quantitative proteomics
title_sort comparative proteomic analysis of human serum before and after liver transplantation using quantitative proteomics
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493459/
https://www.ncbi.nlm.nih.gov/pubmed/31069013
http://dx.doi.org/10.18632/oncotarget.26761
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