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Evaluation of gilteritinib in combination with chemotherapy in preclinical models of FLT3-ITD(+) acute myeloid leukemia

Activating internal tandem duplication (ITD) and tyrosine kinase domain (TKD) point mutations in Fms-like tyrosine kinase 3 (FLT3) occur in approximately 30% of patients with acute myeloid leukemia (AML), and confer a poor prognosis with standard cytarabine/anthracycline or azacitidine-based chemoth...

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Detalles Bibliográficos
Autores principales:	Ueno, Yoko, Mori, Masamichi, Kamiyama, Yoshiteru, Saito, Rika, Kaneko, Naoki, Isshiki, Eriko, Kuromitsu, Sadao, Takeuchi, Masahiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493465/ https://www.ncbi.nlm.nih.gov/pubmed/31069015 http://dx.doi.org/10.18632/oncotarget.26811

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