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Glibenclamide, a Sur1-Trpm4 antagonist, does not improve outcome after collagenase-induced intracerebral hemorrhage

The sulfonylurea 1 transient receptor potential melastatin 4 (Sur1-Trpm4) receptor is selectively expressed after intracerebral hemorrhage (ICH). This upregulation contributes to increases in intracellular sodium. Water follows sodium through aquaporin channels, leading to cytotoxic edema. Even afte...

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Detalles Bibliográficos
Autores principales:	Wilkinson, Cassandra M., Brar, Paul S., Balay, Celine J., Colbourne, Frederick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494051/ https://www.ncbi.nlm.nih.gov/pubmed/31042750 http://dx.doi.org/10.1371/journal.pone.0215952

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