Cargando…

Phase III Trial of PROSTVAC in Asymptomatic or Minimally Symptomatic Metastatic Castration-Resistant Prostate Cancer

PURPOSE: PROSTVAC, a viral vector–based immunotherapy, prolonged median overall survival (OS) by 8.5 months versus placebo in metastatic castration-resistant prostate cancer in a phase II study. This phase III study further investigated those findings. PATIENTS AND METHODS: Patients were randomly as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gulley, James L., Borre, Michael, Vogelzang, Nicholas J., Ng, Siobhan, Agarwal, Neeraj, Parker, Chris C., Pook, David W., Rathenborg, Per, Flaig, Thomas W., Carles, Joan, Saad, Fred, Shore, Neal D., Chen, Liddy, Heery, Christopher R., Gerritsen, Winald R., Priou, Frank, Langkilde, Niels C., Novikov, Andrey, Kantoff, Philip W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Clinical Oncology 2019
Materias:	RAPID COMMUNICATION
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494360/ https://www.ncbi.nlm.nih.gov/pubmed/30817251 http://dx.doi.org/10.1200/JCO.18.02031

Ejemplares similares

Myocarditis in a patient treated with Nivolumab and PROSTVAC: a case report
por: Monge, Cecilia, et al.
Publicado: (2018)

Elucidating immunologic mechanisms of PROSTVAC cancer immunotherapy
por: Mandl, Stefanie J, et al.
Publicado: (2014)

Neoadjuvant PROSTVAC prior to radical prostatectomy enhances T-cell infiltration into the tumor immune microenvironment in men with prostate cancer
por: Abdul Sater, Houssein, et al.
Publicado: (2020)

Current and Emerging Treatment Options for Castration-Resistant Prostate Cancer: A Focus on Immunotherapy
por: Gerritsen, Winald R., et al.
Publicado: (2011)

Rucaparib in Men With Metastatic Castration-Resistant Prostate Cancer Harboring a BRCA1 or BRCA2 Gene Alteration
por: Abida, Wassim, et al.
Publicado: (2020)

Development and validation of a Luminex assay for detection of a predictive biomarker for PROSTVAC-VF therapy
por: Lucas, Julie L., et al.
Publicado: (2017)

Pain predicts overall survival in men with metastatic castration-resistant prostate cancer treated with radium-223
por: Roviello, Giandomenico, et al.
Publicado: (2018)

Development of a dual targeting scaffold of SET7/MLL inhibitor for castration-resistant prostate cancer treatment
por: Li, Guodong, et al.
Publicado: (2023)

A Clinical Evaluation of Enzalutamide in Metastatic Castration-Sensitive Prostate Cancer: Guiding Principles for Treatment Selection and Perspectives on Research
por: Laccetti, Andrew L, et al.
Publicado: (2020)

Androgen receptor-mediated downregulation of microRNA-221 and -222 in castration-resistant prostate cancer
por: Gui, Bin, et al.
Publicado: (2017)

Real‐world outcomes of sipuleucel‐T treatment in PROCEED, a prospective registry of men with metastatic castration‐resistant prostate cancer
por: Higano, Celestia S., et al.
Publicado: (2019)

Early alkaline phosphatase dynamics as biomarker of survival in metastatic castration-resistant prostate cancer patients treated with radium-223
por: van der Doelen, Maarten J., et al.
Publicado: (2021)

Time to disease-related pain and first opioid use in patients with metastatic castration-resistant prostate cancer treated with sipuleucel-T
por: Small, E J, et al.
Publicado: (2014)

Improved efficacy of mitoxantrone in patients with castration-resistant prostate cancer after vaccination with GM-CSF-transduced allogeneic prostate cancer cells
por: van Dodewaard-de Jong, Joyce M., et al.
Publicado: (2015)

Treatment evolution for metastatic castration‐resistant prostate cancer with recent introduction of novel agents: retrospective analysis of real‐world data
por: Flaig, Thomas W., et al.
Publicado: (2015)

Pharmacokinetic Aspects of the Two Novel Oral Drugs Used for Metastatic Castration-Resistant Prostate Cancer: Abiraterone Acetate and Enzalutamide
por: Benoist, Guillemette E., et al.
Publicado: (2016)

A prognostic index model for predicting overall survival in patients with metastatic castration-resistant prostate cancer treated with abiraterone acetate after docetaxel
por: Chi, K. N., et al.
Publicado: (2016)

Rapid Communication: MicroRNA co-expression network reveals apoptosis in the reproductive tract during molting in laying hens(1)(,)(2)
por: Kim, J., et al.
Publicado: (2017)

A Phase I Trial of Pox PSA vaccines (PROSTVAC(®)-VF) with B7-1, ICAM-1, and LFA-3 co-stimulatory molecules (TRICOM™) in Patients with Prostate Cancer
por: DiPaola, RS, et al.
Publicado: (2006)

False Negatives for Remote Life Detection on Ocean-Bearing Planets: Lessons from the Early Earth
por: Reinhard, Christopher T., et al.
Publicado: (2017)

Criteria for short QT interval based on a new QT-heart rate adjustment formula
por: Rabkin, Simon W.
Publicado: (2017)

Detection of West Nile virus lineage 2 in North‐Eastern Spain (Catalonia)
por: Busquets, Núria, et al.
Publicado: (2018)

Supramolecular polymerization of a ureidopyrimidinone‐based [2]catenane prepared via ring‐closing metathesis
por: Teunissen, Abraham J. P., et al.
Publicado: (2017)

SARS‐CoV‐2 asymptomatic and symptomatic patients and risk for transfusion transmission
por: Corman, Victor M., et al.
Publicado: (2020)

The cyclic behavior of a cytoplasmic factor controlling nuclear membrane breakdown
por: Wasserman, W. J., et al.
Publicado: (1978)

Quantification of a peptide standard using the intrinsic fluorescence of tyrosine
por: Preston, George W., et al.
Publicado: (2016)

(Non‐)donor demographics, donation willingness, and the donor career
por: Piersma, Tjeerd W., et al.
Publicado: (2019)

Community first response and out-of-hospital cardiac arrest: Identifying priorities for data collection, analysis, and use via the nominal group technique
por: Heffernan, Eithne, et al.
Publicado: (2022)

Fine structural localization of potassium-stimulated rho nitrophenylphosphatase activity in denrites of the cerebral cortex
por: Broderson, S. H., et al.
Publicado: (1978)

A Simple and Sensitive Assay for Measuring Very Small Volumes of Microprinted Solutions
por: Sokolik, Charles W., et al.
Publicado: (2011)

Interim estimates of 2018/19 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, January 2019
por: Skowronski, Danuta M, et al.
Publicado: (2019)

Odorant Receptor from the Southern House Mosquito Narrowly Tuned to the Oviposition Attractant Skatole
por: Hughes, David T., et al.
Publicado: (2010)

Combination of vaccine and immune checkpoint inhibitor is safe with encouraging clinical activity
por: Madan, Ravi A, et al.
Publicado: (2012)

Poxviral-based vaccine elicits immunologic responses in prostate cancer patients
por: Madan, Ravi A, et al.
Publicado: (2014)

Six months' treatment with lifitegrast in patients with moderate-to-severe symptomatic dry eye: a retrospective chart review
por: Atallah, Richard Teofilo, et al.
Publicado: (2019)

Glucocorticoid induction of tyrosine hydroxylase in a continous cell line of rat pheochromocytoma
por: Goodman, R., et al.
Publicado: (1978)

Phospholipidomic Analysis Reveals Changes in Sphingomyelin and Lysophosphatidylcholine Profiles in Plasma from Patients with Neuroborreliosis
por: Łuczaj, W., et al.
Publicado: (2016)

Estimating the infection and case fatality ratio for coronavirus disease (COVID-19) using age-adjusted data from the outbreak on the Diamond Princess cruise ship, February 2020
por: Russell, Timothy W, et al.
Publicado: (2020)

Post-viral effects of COVID-19 in the olfactory system and their implications
por: Xydakis, Michael S, et al.
Publicado: (2021)

Case series: indoor-photosensitivity caused by fluorescent lamps in patients treated with vemurafenib for metastatic melanoma
por: Boudewijns, Steve, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_sudrblt8to8pahtm41tsgdvf8g