Cargando…

CARD9(+) Microglia Promote Antifungal Immunity via IL-1β and CXCL1-mediated Neutrophil Recruitment

The C-type lectin receptor–Syk adaptor CARD9 facilitates protective antifungal immunity within the central nervous system (CNS), as human CARD9-deficiency causes fungal-specific CNS-targeted infection susceptibility. CARD9 promotes neutrophil recruitment to the fungal-infected CNS, which mediates fu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Drummond, Rebecca A., Swamydas, Muthulekha, Oikonomou, Vasileios, Zhai, Bing, Dambuza, Ivy M., Schaefer, Brian C., Bohrer, Andrea C., Mayer-Barber, Katrin D., Lira, Sergio A., Iwakura, Yoichiro, Filler, Scott G., Brown, Gordon D., Hube, Bernhard, Naglik, Julian R., Hohl, Tobias M., Lionakis, Michail S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494474/ https://www.ncbi.nlm.nih.gov/pubmed/30996332 http://dx.doi.org/10.1038/s41590-019-0377-2

Ejemplares similares

Mechanistic Insights into the Role of C-Type Lectin Receptor/CARD9 Signaling in Human Antifungal Immunity
por: Drummond, Rebecca A., et al.
Publicado: (2016)

Development of a novel β-1,6-glucan–specific detection system using functionally-modified recombinant endo-β-1,6-glucanase
por: Yamanaka, Daisuke, et al.
Publicado: (2020)

Human CARD9: A Critical Molecule of Fungal Immune Surveillance
por: Drummond, Rebecca A., et al.
Publicado: (2018)

Candidalysin Is Required for Neutrophil Recruitment and Virulence During Systemic Candida albicans Infection
por: Swidergall, Marc, et al.
Publicado: (2019)

Host immune status-specific production of gliotoxin and bis-methyl-gliotoxin during invasive aspergillosis in mice
por: Sugui, Janyce A., et al.
Publicado: (2017)

CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System
por: Drummond, Rebecca A., et al.
Publicado: (2015)

The role of Syk/CARD9 coupled C-type lectins in antifungal immunity
por: Drummond, Rebecca A, et al.
Publicado: (2011)

Autoimmune Regulator Deficiency Results in a Decrease in STAT1 Levels in Human Monocytes
por: Zimmerman, Ofer, et al.
Publicado: (2017)

Immune responses to human fungal pathogens and therapeutic prospects
por: Lionakis, Michail S., et al.
Publicado: (2023)

Chemokine Receptor Ccr1 Drives Neutrophil-Mediated Kidney Immunopathology and Mortality in Invasive Candidiasis
por: Lionakis, Michail S., et al.
Publicado: (2012)

The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes
por: Kasper, Lydia, et al.
Publicado: (2018)

Deciphering mechanisms of immune escape to inform immunotherapeutic strategies in multiple myeloma
por: Swamydas, Muthulekha, et al.
Publicado: (2022)

Colitis susceptibility in p47(phox−/−) mice is mediated by the microbiome
por: Falcone, E. Liana, et al.
Publicado: (2016)

EphA2 is an epithelial cell pattern recognition receptor for fungal β-glucans
por: Swidergall, Marc, et al.
Publicado: (2017)

Unique molecular signature in mucolipidosis type IV microglia
por: Cougnoux, Antony, et al.
Publicado: (2019)

It’s all in your head: antifungal immunity in the brain
por: Snarr, Brendan D, et al.
Publicado: (2020)

The Missing Link between Candida albicans Hyphal Morphogenesis and Host Cell Damage
por: Wilson, Duncan, et al.
Publicado: (2016)

Candidalysin: discovery and function in Candida albicans infections
por: Naglik, Julian R, et al.
Publicado: (2019)

Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury
por: Sato, Atsushi, et al.
Publicado: (2012)

C-type lectins in immunity: recent developments
por: Dambuza, Ivy M, et al.
Publicado: (2015)

Vactosertib, a novel TGF-β1 type I receptor kinase inhibitor, improves T-cell fitness: a single-arm, phase 1b trial in relapsed/refractory multiple myeloma
por: Malek, Ehsan, et al.
Publicado: (2023)

Unmasking a fungal fire
por: Dambuza, Ivy M., et al.
Publicado: (2023)

New insights into innate immune control of systemic candidiasis
por: Lionakis, Michail S.
Publicado: (2014)

EphA2 Is a Neutrophil Receptor for Candida albicans that Stimulates Antifungal Activity during Oropharyngeal Infection
por: Swidergall, Marc, et al.
Publicado: (2019)

Caspase recruitment domain (CARD) family (CARD9, CARD10, CARD11, CARD14 and CARD15) are increased during active inflammation in patients with inflammatory bowel disease
por: Yamamoto-Furusho, Jesús K., et al.
Publicado: (2018)

From EuCARD to EuCARD-2
por: Chaudron, M
Publicado: (2013)

From EuCARD to EuCARD-2
por: Chaudron, M
Publicado: (2013)

Java Card technology for Smart Cards : architecture and programmer's guide /
por: Chen, Zhiqun, 1969-
Publicado: (2000)

Microglia in Retinal Degeneration
por: Rashid, Khalid, et al.
Publicado: (2019)

Fungal CNS Infections in Africa: The Neuroimmunology of Cryptococcal Meningitis
por: Mohamed, Sally H., et al.
Publicado: (2022)

Repopulated microglia induce expression of Cxcl13 with differential changes in Tau phosphorylation but do not impact amyloid pathology
por: Karaahmet, Berke, et al.
Publicado: (2022)

Inside PC Card: CardBus and PCMCIA design
por: Imdad-Haque, Faisal
Publicado: (1996)

T Cell Antifungal Immunity and the Role of C-Type Lectin Receptors
por: Speakman, Emily A., et al.
Publicado: (2020)

Candida and Host Determinants of Susceptibility to Invasive Candidiasis
por: Lionakis, Michail S., et al.
Publicado: (2013)

B Cells Protect T Cell-deficient mice from Cryptococcal Brain Invasion
por: Davis, Michael J., et al.
Publicado: (2017)

Recent advances in understanding inherited deficiencies in immunity to infections
por: Constantine, Gregory M., et al.
Publicado: (2020)

Pathogenesis and virulence of Candida albicans
por: Lopes, José Pedro, et al.
Publicado: (2021)

C5‐C5aR1‐mediated immune responses during fungal infection: Clinical and translational implications
por: Desai, Jigar V., et al.
Publicado: (2023)

CarDS-Plus ECG Platform: Development and Feasibility Evaluation of a Multiplatform Artificial Intelligence Toolkit for Portable and Wearable Device Electrocardiograms
por: Shankar, Sumukh Vasisht, et al.
Publicado: (2023)

Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation
por: Holliday, Michael J., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_l4n2g1t6n3hd8ndcrc73i79a12