Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM

The human R2TP complex (RUVBL1-RUVBL2-RPAP3-PIH1D1) is an HSP90 co-chaperone required for the maturation of several essential multiprotein complexes, including RNA polymerase II, small nucleolar ribonucleoproteins, and PIKK complexes such as mTORC1 and ATR-ATRIP. RUVBL1-RUVBL2 AAA-ATPases are also p...

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Detalles Bibliográficos
Autores principales: Muñoz-Hernández, Hugo, Pal, Mohinder, Rodríguez, Carlos F., Fernandez-Leiro, Rafael, Prodromou, Chrisostomos, Pearl, Laurence H., Llorca, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494491/
https://www.ncbi.nlm.nih.gov/pubmed/31049401
http://dx.doi.org/10.1126/sciadv.aaw1616

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