Transposon Molecular Domestication and the Evolution of the RAG Recombinase

Domestication of a transposon to give rise to the RAG1/RAG2 recombinase and V(D)J recombination was a pivotal event in the evolution of the jawed vertebrate adaptive immune system. The evolutionary adaptations that transformed the ancestral RAG transposase into a RAG recombinase with appropriately r...

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Detalles Bibliográficos
Autores principales: Zhang, Yuhang, Cheng, Tat Cheung, Huang, Guangrui, Lu, Qingyi, Surleac, Marius D., Mandell, Jeffrey D., Pontarotti, Pierre, Petrescu, Andrei J., Xu, Anlong, Xiong, Yong, Schatz, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494689/
https://www.ncbi.nlm.nih.gov/pubmed/30971819
http://dx.doi.org/10.1038/s41586-019-1093-7

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