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Structural Characteristics of Seven IL-32 Variants

IL-32 exists as seven mRNA transcripts that can translate into distinct individual IL-32 variants with specific protein domains. These translated protein domains of IL-32 variants code for specific functions that allow for interaction with different molecules intracellularly or extracellularly. The...

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Autores principales: Sohn, Dong Hyun, Nguyen, Tam T., Kim, Sinae, Shim, Saerok, Lee, Siyoung, Lee, Youngmin, Jhun, Hyunjhung, Azam, Tania, Kim, Joohee, Kim, Soohyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494766/
https://www.ncbi.nlm.nih.gov/pubmed/31089435
http://dx.doi.org/10.4110/in.2019.19.e8
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author Sohn, Dong Hyun
Nguyen, Tam T.
Kim, Sinae
Shim, Saerok
Lee, Siyoung
Lee, Youngmin
Jhun, Hyunjhung
Azam, Tania
Kim, Joohee
Kim, Soohyun
author_facet Sohn, Dong Hyun
Nguyen, Tam T.
Kim, Sinae
Shim, Saerok
Lee, Siyoung
Lee, Youngmin
Jhun, Hyunjhung
Azam, Tania
Kim, Joohee
Kim, Soohyun
author_sort Sohn, Dong Hyun
collection PubMed
description IL-32 exists as seven mRNA transcripts that can translate into distinct individual IL-32 variants with specific protein domains. These translated protein domains of IL-32 variants code for specific functions that allow for interaction with different molecules intracellularly or extracellularly. The longest variant is IL-32γ possessing 234 amino acid residues with all 11 protein domains, while the shortest variant is IL-32α possessing 131 amino acid residues with three of the protein domains. The first domain exists in 6 variants except IL-32δ variant, which has a distinct translation initiation codon due to mRNA splicing. The last eleventh domain is common domain for all seven IL-32 variants. Numerous studies in different fields, such as inflammation, autoimmunity, pathogen infection, and cancer biology, have claimed the specific biological activity of individual IL-32 variant despite the absence of sufficient data. There are 4 additional IL-32 variants without proper transcripts. In this review, the structural characteristics of seven IL-32 transcripts are described based on the specific protein domains.
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spelling pubmed-64947662019-05-14 Structural Characteristics of Seven IL-32 Variants Sohn, Dong Hyun Nguyen, Tam T. Kim, Sinae Shim, Saerok Lee, Siyoung Lee, Youngmin Jhun, Hyunjhung Azam, Tania Kim, Joohee Kim, Soohyun Immune Netw Review Article IL-32 exists as seven mRNA transcripts that can translate into distinct individual IL-32 variants with specific protein domains. These translated protein domains of IL-32 variants code for specific functions that allow for interaction with different molecules intracellularly or extracellularly. The longest variant is IL-32γ possessing 234 amino acid residues with all 11 protein domains, while the shortest variant is IL-32α possessing 131 amino acid residues with three of the protein domains. The first domain exists in 6 variants except IL-32δ variant, which has a distinct translation initiation codon due to mRNA splicing. The last eleventh domain is common domain for all seven IL-32 variants. Numerous studies in different fields, such as inflammation, autoimmunity, pathogen infection, and cancer biology, have claimed the specific biological activity of individual IL-32 variant despite the absence of sufficient data. There are 4 additional IL-32 variants without proper transcripts. In this review, the structural characteristics of seven IL-32 transcripts are described based on the specific protein domains. The Korean Association of Immunologists 2019-04-16 /pmc/articles/PMC6494766/ /pubmed/31089435 http://dx.doi.org/10.4110/in.2019.19.e8 Text en Copyright © 2019. The Korean Association of Immunologists https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sohn, Dong Hyun
Nguyen, Tam T.
Kim, Sinae
Shim, Saerok
Lee, Siyoung
Lee, Youngmin
Jhun, Hyunjhung
Azam, Tania
Kim, Joohee
Kim, Soohyun
Structural Characteristics of Seven IL-32 Variants
title Structural Characteristics of Seven IL-32 Variants
title_full Structural Characteristics of Seven IL-32 Variants
title_fullStr Structural Characteristics of Seven IL-32 Variants
title_full_unstemmed Structural Characteristics of Seven IL-32 Variants
title_short Structural Characteristics of Seven IL-32 Variants
title_sort structural characteristics of seven il-32 variants
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494766/
https://www.ncbi.nlm.nih.gov/pubmed/31089435
http://dx.doi.org/10.4110/in.2019.19.e8
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